Results 61 to 70 of about 1,081,959 (292)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

The relation between the microscopic structure and the wood density of European beech (Fagus sylvatica L.)

Journal of Forest Science, 2008
The aim of this study was to compare the structure of beech juvenile and mature wood in relation to wood density. The comparative analysis between juvenile and mature wood examined the diameter of vessels, the width and height of pith rays, and the ...
V. Gryc, H. Vavrčík, M. Rybníček, E. Přemyslovská   +3 more
doaj   +1 more source

THE ROLE OF THE HUMAN AND STRUCTURAL CAPITAL, INTELLECTUAL CAPITAL AND BUSINESS PERFORMANCE [PDF]

Russian Journal of Agricultural and Socio-Economic Sciences, 2019
This study aims to determine the relationship of the implementation of Intellectual Capital to Business Performance on the manufacture company in the province of Banten. Especially purpose of this research is to know the relationship of the Human Capital
Rays M., Murwaningsari E.
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Microbiome differences between wild and aquarium whitespotted eagle rays (Aetobatus narinari)

Animal Microbiome, 2022
Background Animal-associated microbiomes can be influenced by both host and environmental factors. Comparing wild animals to those in zoos or aquariums can help disentangle the effects of host versus environmental factors, while also testing whether ...
Ana G. Clavere-Graciette, Mary E. McWhirt, Lisa A. Hoopes, Kim Bassos-Hull, Krystan A. Wilkinson, Frank J. Stewart, Zoe A. Pratte   +6 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Elasmobranch microbiomes: emerging patterns and implications for host health and ecology

Animal Microbiome, 2021
Elasmobranchs (sharks, skates and rays) are of broad ecological, economic, and societal value. These globally important fishes are experiencing sharp population declines as a result of human activity in the oceans.
Cameron T. Perry, Zoe A. Pratte, Ana Clavere-Graciette, Kim B. Ritchie, Robert E. Hueter, Alisa L. Newton, G. Christopher Fischer, Elizabeth A. Dinsdale, Michael P. Doane, Krystan A. Wilkinson, Kim Bassos-Hull, Kady Lyons, Alistair D. M. Dove, Lisa A. Hoopes, Frank J. Stewart   +14 more
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Elasmobranch species in the artisanal fishery of Sucre State, Venezuela

Ciencias Marinas, 2019
A wide diversity of elasmobranch species has been reported for waters off Venezuela; however, information regarding this group is lacking for most coastal regions.
Raquel Marquez, Rafael Tavares, Luis Alejandro Ariza   +2 more
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source