Results 1 to 10 of about 112,246 (165)

Identification of potentially actionable genetic variants in epithelial ovarian cancer: a retrospective cohort study [PDF]

npj Precision Oncology
Ovarian cancer is the most lethal gynecologic malignancy, mainly due to late-stage diagnosis, frequent recurrences, and eventually therapy resistance.
Charlotte Fieuws, Joni Van der Meulen, Kristiaan Proesmans, Emiel A. De Jaeghere, Siebe Loontiens, Jo Van Dorpe, Philippe Tummers, Hannelore Denys, Koen Van de Vijver, Kathleen B. M. Claes   +9 more
doaj   +3 more sources

Genomic characterization and histologic analysis of uterine leiomyosarcoma arising from leiomyoma with bizarre nuclei. [PDF]

J Pathol
Abstract Leiomyoma with bizarre nuclei (LM‐BN) is a rare variant of leiomyoma with a benign clinical course. In contrast, leiomyosarcoma (LMS) is a high‐grade, malignant neoplasm characterized by high recurrence rates and poor survival. While LM‐BN and LMS show distinct morphologies, they share similar immunoprofiles and molecular alterations, with ...
Felicelli C, Lu X, Coty-Fattal Z, Feng Y, Yin P, Schipma MJ, Kim JJ, Jennings LJ, Bulun SE, Wei JJ.   +9 more
europepmc   +2 more sources

Current status of precision oncology in adult glioblastoma. [PDF]

Mol Oncol
This review summarizes the current status of precision oncology – targeted therapies based on individual genetic profiles – in glioblastoma. Although some treatments show promise, their applicability and effectiveness remain limited, underlining the need for innovative approaches.
Weller J, Potthoff AL, Zeyen T, Schaub C, Duffy C, Schneider M, Herrlinger U.   +6 more
europepmc   +2 more sources

Causes of necrotic features in fine-needle aspirates from cervical lymph nodes [PDF]

Journal of Pathology and Translational Medicine, 2021
Background Lymph node fine-needle aspiration (LN FNA) cytology indicates necrosis in various diseases. Dominant necrotic features make the diagnosis of underlying conditions very difficult.
Young Jin Seo, Hyeongchan Shin, Hye Won Lee, Hye Ra Jung   +3 more
doaj   +1 more source

Current updates of CRISPR/Cas9‐mediated genome editing and targeting within tumor cells: an innovative strategy of cancer management

Cancer Communications, Volume 42, Issue 12, Page 1257-1287, December 2022., 2022
Abstract Clustered regularly interspaced short palindromic repeats‐associated protein (CRISPR/Cas9), an adaptive microbial immune system, has been exploited as a robust, accurate, efficient and programmable method for genome targeting and editing. This innovative and revolutionary technique can play a significant role in animal modeling, in vivo genome
Khaled S. Allemailem, Mohammed A Alsahli, Ahmad Almatroudi, Faris Alrumaihi, Fahd Khaleefah Alkhaleefah, Arshad Husain Rahmani, Amjad Ali Khan   +6 more
wiley   +1 more source

How microRNA and transcription factor co-regulatory networks affect osteosarcoma cell proliferation. [PDF]

PLoS Computational Biology, 2013
Osteosarcomas (OS) are complex bone tumors with various genomic alterations. These alterations affect the expression and function of several genes due to drastic changes in the underlying gene regulatory network.
Kathrin Poos, Jan Smida, Michaela Nathrath, Doris Maugg, Daniel Baumhoer, Eberhard Korsching   +5 more
doaj   +1 more source

Genomic characterization reveals distinct mutation landscapes and therapeutic implications in neuroendocrine carcinomas of the gastrointestinal tract

Cancer Communications, Volume 42, Issue 12, Page 1367-1386, December 2022., 2022
Abstract Background Neuroendocrine carcinomas of the gastrointestinal tract (GI‐NECs) remain a disease of grim prognosis with limited therapeutic options. Their molecular characteristics are still undefined. This study aimed to explore the underlying genetic basis and heterogeneity of GI‐NECs.
Huanwen Wu, Zicheng Yu, Yueping Liu, Lei Guo, Lianghong Teng, Lingchuan Guo, Li Liang, Jing Wang, Jie Gao, Ruiyu Li, Ling Yang, Xiu Nie, Dan Su, Zhiyong Liang   +13 more
wiley   +1 more source

Evaluating of the Effects of Sub-MIC Concentrations of Gentamicin on Biofilm Formation in Clinical Isolates of Pseudomonas aeruginosa [PDF]

Iranian Journal of Pathology, 2021
Background & Objective: The ability of Pseudomonas aeruginosa to form biofilm has an important role in establishment of chronic phase of infections. Biofilm formation can be affected by antibiotics sub-MIC concentrations. The principal aim of the present
Zahra Yousefpour, Fateme Davarzani, Parviz Owlia   +2 more
doaj   +1 more source

Annexin Expression in Cholangiocarcinoma, and Metastatic Pancreatic Ductal Adenocarcinoma “Is it be Helpful for Differential Diagnosis of These Tumors in the Liver?” [PDF]

Iranian Journal of Pathology, 2021
Background & Objective: Differential diagnosis between cholangiocarcinoma (CCA) and metastatic pancreatic ductal adenocarcinoma (PDA) in the liver is difficult and so far, no specific immunohistochemical marker is reported to differentiate these two ...
Bita Geramizadeh, Mahsa Sehat, Azam Mehrmozayan, Alireza Shojazadeh   +3 more
doaj   +1 more source

COVID-19 Impact on Modern Virtual Pathology Education: Challenges and Opportunities [PDF]

Iranian Journal of Pathology, 2021
Background & Objective: Pathology education conventional methods have been disrupted by the Corona-Virus Disease 2019 (COVID-19) outbreak, compelling a re-evaluation of the means of educational interactions from the undergraduate to the postgraduate ...
Seyed Esmaeil Azimi Khatibani, Shima Tabatabai   +1 more
doaj   +1 more source