Results 41 to 50 of about 53,919 (139)
Types of combined neurovascular injuries of the extremities
Combined injuries of neurovascular structures are associated with poor results of limb function restoration, often lead to disability and lower quality of life. Aim.
I. V. Pertsov
doaj +1 more source
Inflammation in cardiovascular disease is a dynamic and context‐dependent network rather than a secondary response to injury. Mitochondrial danger signaling links metabolic stress to immune activation through TLR priming, NLRP3 inflammasome amplification, cGAS–STING signaling, and immunometabolic gating, providing a basis for more precise therapeutic ...
Jiaxiang Rong +8 more
wiley +1 more source
Background Recently, screening of colorectal cancer (CRC) patients for mismatch repair/microsatellite instability (MMR/MSI) status is widely practiced due to its potential predictive and prognostic roles and a screening tool to reveal Lynch Syndrome (LS).
Muhammad Ishaque Faizee +7 more
doaj +1 more source
Background. During prenatal development embryonic mammalian heart undergoes deep dynamic changes due to size, structure and functions. Pathological intrauterine hypoxia influences fetal development generally and cardiogeny particularly, it affects the ...
N. S. Petruk
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Delivery Systems for Therapeutic Genome Editing: Challenges, Innovations, and Future Perspectives
Schematic illustration of four emerging CRISPR–Cas delivery platforms defined by distinct design principles and structural features: virus‐mimicking nanosystems (e.g., VLPs), cell‐derived extracellular vesicles, cell‐penetrating peptides, and stimuli‐responsive scaffolds. These platforms enable spatiotemporally controlled delivery of RNPs, mRNA, or DNA
Meijia Yang +9 more
wiley +1 more source
Cell fusion dynamics: mechanisms of multinucleation in osteoclasts and macrophages
Cell–cell fusion is a vital biological process where the membranes of two or more cells merge to form a syncytium. This phenomenon is critical in various physiological and pathological contexts, including embryonic development, tissue repair, immune ...
Hideaki Sabe +2 more
doaj +1 more source
Clinical cases of measles in pregnant women
The aim of the work is to analyze the clinical course of measles in hospitalized pregnant women for the period of 2017–2019 years. Materials and methods. The clinical course of measles was analyzed in 4 pregnant patients with this disease aged from 19
O. V. Riabokon +4 more
doaj +1 more source
ABSTRACT Establishing a successful pregnancy relies on effective communication between the mother and fetus. Small extracellular vesicles (sEVs) are pivotal in facilitating intercellular communication, transferring messenger RNA (mRNA), noncoding RNA (ncRNA), and proteins. Considering the prevalence of in vitro fertilization (IVF) in bovine production,
Amanda de Oliveira Furlan +15 more
wiley +1 more source
In colorectal cancer, high expression of the DNA repair protein EEPD1 correlates with immune exclusion and poor prognosis. This study demonstrates that EEPD1 depletion induces genomic instability, leading to cytosolic DNA accumulation and subsequent activation of the cGAS‐STING‐type I interferon pathway. This cascade remodels the tumor microenvironment
Liyun Huo +8 more
wiley +1 more source
The aim of the study was to investigate the morphological changes in the pancreas of spontaneously hypertensive animals after the combined effect of intermittent normobaric hypoxia (INH) and melatonin. Materials and methods.
R. V. Yanko +3 more
doaj +1 more source

