Results 41 to 50 of about 53,919 (139)

Types of combined neurovascular injuries of the extremities

open access: yesPatologìâ, 2014
Combined injuries of neurovascular structures are associated with poor results of limb function restoration, often lead to disability and lower quality of life. Aim.
I. V. Pertsov
doaj   +1 more source

The Role of Inflammation and Immunity in Cardiovascular Disease: Molecular Mechanisms and Therapeutic Targets

open access: yesMedComm, Volume 7, Issue 8, August 2026.
Inflammation in cardiovascular disease is a dynamic and context‐dependent network rather than a secondary response to injury. Mitochondrial danger signaling links metabolic stress to immune activation through TLR priming, NLRP3 inflammasome amplification, cGAS–STING signaling, and immunometabolic gating, providing a basis for more precise therapeutic ...
Jiaxiang Rong   +8 more
wiley   +1 more source

Concordance between immunohistochemistry and MSI analysis for detection of MMR/MSI status in colorectal cancer patients

open access: yesDiagnostic Pathology
Background Recently, screening of colorectal cancer (CRC) patients for mismatch repair/microsatellite instability (MMR/MSI) status is widely practiced due to its potential predictive and prognostic roles and a screening tool to reveal Lynch Syndrome (LS).
Muhammad Ishaque Faizee   +7 more
doaj   +1 more source

Influence of chronic prenatal hypoxia on the specialized contact apparatus of rat heart ventricles during ontogeny

open access: yesPatologìâ, 2014
Background. During prenatal development embryonic mammalian heart undergoes deep dynamic changes due to size, structure and functions. Pathological intrauterine hypoxia influences fetal development generally and cardiogeny particularly, it affects the ...
N. S. Petruk
doaj   +1 more source

Delivery Systems for Therapeutic Genome Editing: Challenges, Innovations, and Future Perspectives

open access: yesMedComm, Volume 7, Issue 7, July 2026.
Schematic illustration of four emerging CRISPR–Cas delivery platforms defined by distinct design principles and structural features: virus‐mimicking nanosystems (e.g., VLPs), cell‐derived extracellular vesicles, cell‐penetrating peptides, and stimuli‐responsive scaffolds. These platforms enable spatiotemporally controlled delivery of RNPs, mRNA, or DNA
Meijia Yang   +9 more
wiley   +1 more source

Cell fusion dynamics: mechanisms of multinucleation in osteoclasts and macrophages

open access: yesInflammation and Regeneration
Cell–cell fusion is a vital biological process where the membranes of two or more cells merge to form a syncytium. This phenomenon is critical in various physiological and pathological contexts, including embryonic development, tissue repair, immune ...
Hideaki Sabe   +2 more
doaj   +1 more source

Clinical cases of measles in pregnant women

open access: yesPatologìâ, 2020
The aim of the work is to analyze the clinical course of measles in hospitalized pregnant women for the period of 2017–2019 years. Materials and methods. The clinical course of measles was analyzed in 4 pregnant patients with this disease aged from 19
O. V. Riabokon   +4 more
doaj   +1 more source

Coding and Noncoding Uterine Small Extracellular Vesicle Content Differs in the Early Stages of Pregnancies Produced by Artificial Insemination and In Vitro Fertilization in Cattle

open access: yesMolecular Reproduction and Development, Volume 93, Issue 7, July 2026.
ABSTRACT Establishing a successful pregnancy relies on effective communication between the mother and fetus. Small extracellular vesicles (sEVs) are pivotal in facilitating intercellular communication, transferring messenger RNA (mRNA), noncoding RNA (ncRNA), and proteins. Considering the prevalence of in vitro fertilization (IVF) in bovine production,
Amanda de Oliveira Furlan   +15 more
wiley   +1 more source

EEPD1 Inhibition Unleashes Antitumor Immunity in Colorectal Cancer by Activating the cGAS‐STING Pathway

open access: yesAdvanced Science, Volume 13, Issue 34, 19 June 2026.
In colorectal cancer, high expression of the DNA repair protein EEPD1 correlates with immune exclusion and poor prognosis. This study demonstrates that EEPD1 depletion induces genomic instability, leading to cytosolic DNA accumulation and subsequent activation of the cGAS‐STING‐type I interferon pathway. This cascade remodels the tumor microenvironment
Liyun Huo   +8 more
wiley   +1 more source

The combined effect of intermittent normobaric hypoxia and melatonin on the morphological changes of the spontaneously hypertensive rats pancreas

open access: yesPatologìâ, 2019
The aim of the study was to investigate the morphological changes in the pancreas of spontaneously hypertensive animals after the combined effect of intermittent normobaric hypoxia (INH) and melatonin. Materials and methods.
R. V. Yanko   +3 more
doaj   +1 more source

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