Results 21 to 30 of about 53,919 (139)

Identification of potentially actionable genetic variants in epithelial ovarian cancer: a retrospective cohort study

npj Precision Oncology
Ovarian cancer is the most lethal gynecologic malignancy, mainly due to late-stage diagnosis, frequent recurrences, and eventually therapy resistance.
Charlotte Fieuws, Joni Van der Meulen, Kristiaan Proesmans, Emiel A. De Jaeghere, Siebe Loontiens, Jo Van Dorpe, Philippe Tummers, Hannelore Denys, Koen Van de Vijver, Kathleen B. M. Claes   +9 more
doaj   +1 more source

Peculiarities of chemo-resistant HIV/AIDS-associated tuberculosis in patients who died from co-infection

Patologìâ, 2013
Introduction. Today the problem of spread of two epidemics - TB and HIV/AIDS is too complicated in Ukraine. This problem is significantly complicated by the spread of the other world's problem - resistant TB. The growth of the HIV epidemic influences the
A. S. Shalmin, E. M. Raznatovskya, R. М. Yasinskiy   +2 more
doaj   +1 more source

Modulation of the tissue composition of regenerative neuroma by dexamethasone and granulocyte colony-stimulating factor

Patologìâ, 2023
Aim. To evaluate the change of the content of mesenchymal (vimentin-positive) and reparative Schwann (GFAP-positive) cells in the regenerative neuroma of the rat sciatic nerve, taking into account the activity of local homeostasis regulation (CD73 ...
O. M. Grabovyi, N. M. Nevmerzhytska, A. B. Alyokhin, H. B. Kostynskyi, N. V. Rytikova   +4 more
doaj   +1 more source

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Medulloblastomas of the Cerebellum in Children: Clinicopathologic Comparison

Patologìâ, 2017
Embryonal neuroepithelial tumours of the brain, grade IV are mainly observed in children and are characterized by rapid metastatic spread and frequent recurrence.
V. V. Morgun, О. G. Chernenko, I. A. Malovichko, S. O. Rudenko, Т. A. Malysheva, V. P. Sil’chenko, L. M. Verbova   +6 more
doaj   +1 more source

Ovarian Cancer: Epidemiology, Disease Mechanisms, New Diagnosis and Treatment Strategies, and Research Directions

iNew Medicine, EarlyView.
ABSTRACT Ovarian cancer (OC) continues to be the deadliest gynecological malignancy and a significant cause of cancer‐related mortality among women worldwide. Standard treatment strategies typically entail platinum‐based chemotherapy in conjunction with cytoreductive surgery.
Zunera Khalid, Weirong Fan, Farah Nazir, Yixiang Xing, Tengchuan Jin   +4 more
wiley   +1 more source

A new perspective on diagnostic strategies concerning the potential of saliva-based miRNA signatures in oral cancer

Diagnostic Pathology
Oral cancer, the most prevalent cancer worldwide, is far more likely to occur after the age of forty-five, according to the World Health Organization.
Monisha Prasad, Ramya Sekar, Malarveni Damodaran Lakshmi Priya, Sudhir Rama Varma, Mohmed Isaqali Karobari   +4 more
doaj   +1 more source

Senotherapeutics for Knee Osteoarthritis

Medicinal Research Reviews, EarlyView.
ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman, Girish Pattappa, Patrick Pann, Stephan Reppenhagen, Maximilian Rudert, Peter Angele, Denitsa Docheva   +6 more
wiley   +1 more source

Ineffectiveness of immune checkpoint inhibitors in prostate cancer: is it just a question of ‘‐mabs’?

The Journal of Pathology, EarlyView.
Abstract Prostate cancer (PCa) is the second most common type of neoplasm, currently treated with a variety of therapeutic agents. Although advances in treatment over the past decade have improved overall survival, patients with advanced PCa eventually progress from hormone‐sensitive PCa to metastatic castration‐resistant PCa.
Giuseppe Schepisi, Irene Torresan, Emilio Francesco Giunta, Sara Bleve, Nicole Brighi, Elisa Tassinari, Sofia Zanuccoli, Maria Concetta Cursano, Cristian Lolli   +8 more
wiley   +1 more source

Activity of matrix metalloproteinases and their tissue inhibitors in serum in chronic granulating periodontitis

Patologìâ, 2019
Aim. The aim of the work is to study the activity of matrix metalloproteinases and their tissue inhibitors in chronic granular periodontitis. Materials and methods. We examined serum of 15 patients with chronic granulating periodontitis and 15 healthy
D. I. Haidash, I. S. Haidash, O. О. Bondar, Yu. О. Yevtushenko, O. I. Haidash   +4 more
doaj   +1 more source