Results 21 to 30 of about 49,770 (119)

Protease activated receptors 1 and 4 sensitize TRPV1 in nociceptive neurones

Molecular Pain, 2010
Protease-activated receptors (PAR1-4) are activated by proteases released by cell damage or blood clotting, and are known to be involved in promoting pain and hyperalgesia.
Magherini Pier C, Reeh Peter, Hechtfischer Sabine C, Prandini Massimiliano, Kinsey Anna M, Vellani Vittorio, Giacomoni Chiara, McNaughton Peter A   +7 more
doaj   +1 more source

Natural Products in Cancer Prevention and Therapy: Current Challenges and Future Directions

MedComm, Volume 7, Issue 2, February 2026.
Natural products play a pivotal role in cancer therapy. They induce cancer cell death by reprogramming four metabolic pathways while precisely targeting the tumor microenvironment and immune cells. These compounds not only leverage novel delivery systems for innovative applications but also demonstrate unique therapeutic efficacy across clinical stages:
Ruimiao Qian, Jun Ge, Ni Fan, Zheng Sun, Chengcheng Zhao, Yujiao Sun, Yingpeng Li, Yunfei Li, Hui Fu   +8 more
wiley   +1 more source

Multiple germline sequence variants with potential cancer risk uncovered by exome sequencing in an anatomic lab donor cadaver with multiple cancer lesions

Human Pathology Reports
Ovarian cancer is the leading cause of death among gynecological cancers in most developed countries, with many patients developing chemotherapy resistance leaving them with a 5-year survival rate of 
Jessica Liang, Arben Santo, Peter Samuel, Lin Kang, Katherine Salim, Tiffany Carpenetti, Ramu Anandakrishnan, Pawel Michalak, Harold Garner, Robin T. Varghese   +9 more
doaj   +1 more source

Cortical plasticity as a new endpoint measurement for chronic pain

Molecular Pain, 2011
Animal models of chronic pain are widely used to investigate basic mechanisms of chronic pain and to evaluate potential novel drugs for treating chronic pain.
Zhuo Min
doaj   +1 more source

Breast Cancer: Molecular Pathogenesis, Targeted Therapy, Screening, and Prevention

MedComm, Volume 7, Issue 1, January 2026.
The review manuscript examines the molecular pathogenesis, screening, prevention advances, and evolving targeted therapies in breast cancer. It highlights the integration of AI and multiomics for precision prevention and personalized treatment, pointing toward future directions in equitable cancer care.
Huijun Lei, Jinzhen Fu, Wei Gu, Hongjin Qiao, Huixue Guo, Zijian Chen, San Ming Wang, Tianhui Chen   +7 more
wiley   +1 more source

Kikuchi-Fujimoto disease in the regional lymph nodes in a patient with concurrent malignant phyllodes tumour

Human Pathology Reports
Kikuchi-Fujimoto disease (KFD, histiocytic necrotizing lymphadenitis) is a rare, benign disease in which the presenting clinical and radiological features often result in misclassification as a malignant process. We present the first report of concurrent
Ciara Murray, Rosemarie Tremblay-LeMay, Jan Delabie, Andrea Covelli, Susan J. Done   +4 more
doaj   +1 more source

Changes of microRNAs-192, 196a and 203 correlate with Barrett's esophagus diagnosis and its progression compared to normal healthy individuals

Diagnostic Pathology, 2011
Background Barrett's esophagus (BE) is a disease with a rising prevalence in western countries probably due to the unhealthy lifestyle. In significant number of cases it develops to esophageal adenocarcinoma.
Luzna Pavla, Gregar Jan, Uberall Ivo, Radova Lenka, Prochazka Vlastimil, Ehrmann Jiri   +5 more
doaj   +1 more source

Melanoma: Pathogenesis and Targeted Therapy

MedComm, Volume 7, Issue 1, January 2026.
The treatment landscape for advanced melanoma has evolved significantly. BRAF–MEK inhibitor combinations are standard for BRAF‐mutant melanoma, whereas targeting NRAS mutations is more challenging, with MEK inhibitors like tunlametinib emerging as an option.
Yang Fu, Jie Liu, Zeming Mo, Bin Wang, Yaotiao Deng, Yu Jiang   +5 more
wiley   +1 more source

Adenoid cystic carcinoma in situ of the breast: A case report

Human Pathology Reports
Adenoid cystic carcinoma (AdCC) is a rare entity in the breast. It is a biphasic malignancy with a slow-growing nature and a relatively favorable prognosis.
Asad Ur Rehman, Noelle A. Rolle, Intisar Ghleilib, Di Ai   +3 more
doaj   +1 more source

Organoids in Cancer Research and Regenerative Medicine: Current Status, Challenges, and Future Prospects

MedComm, Volume 7, Issue 1, January 2026.
The management of cancer and tissue regeneration remains a substantial challenge to global health. Organoids, which are stem cell‐derived three‐dimensional multicellular structures, are revolutionizing biomedical research. Therefore, this review highlights their applications in cancer research and regenerative medicine, while discussing current ...
Ruiyang Li, Yuezhou Wu, Zhu'anzhen Zheng, Fengjin Zhou, Ke Xu, Jiacan Su   +5 more
wiley   +1 more source