Results 31 to 40 of about 49,770 (119)

A molecularly-confirmed extraskeletal myxoid chondrosarcoma with dual gene rearrangements, EWSR1::NR4A3 and HAPLN1::EDIL3 fusion

Human Pathology Reports
Background: Extraskeletal myxoid chondrosarcoma (EMC) is a rare mesenchymal neoplasm with uncertain origin that is commonly seen in the lower extremities.
Dong Ren, Katherine Wei, Ryan O’connell   +2 more
doaj   +1 more source

Recurrent central nervous system Rosai-Dorfman disease with KRAS mutation: a case report

Diagnostic Pathology, 2023
Background Rosai-Dorfman disease (RDD) is a rare, non-Langerhans cell histiocytosis of unknown etiology. we report a very rare case of recurrent central nervous system RDD with KRAS gene mutation and review the literature to improve our understanding of ...
Qingyang Wang, Hongxiang Ren, Liyuan Zheng, Juan Wang, Dingrong Zhong   +4 more
doaj   +1 more source

Wnt Signaling Pathway: Biological Function, Diseases, and Therapeutic Interventions

MedComm, Volume 7, Issue 1, January 2026.
The Wnt signaling pathway is essential for development and tissue homeostasis, while its dysregulation drives diverse diseases. This review systematically outlines its components, functions, regulators, and preclinical models, highlighting secreted frizzled‐related proteins (SFRPs) as context‐dependent, biphasic modulators.
Xiaoyu Jin, Jiahui Wang, Runyi Cao, Dongsheng Jiang   +3 more
wiley   +1 more source

Postoperative recurrence of mixed extragonadal germ cell tumor in the right shoulder: a case report

Diagnostic Pathology, 2023
Background Extragonadal germ cell tumours (EGGCTs) originated in Shoulder are extremely rare, with 1 case described in the literature. We report a case of a patient with a primary Right Shoulder mixed EGGCT.
Yao Li, Xiang Huang, Xue Meng, Yuqing Luo, Shuai Luo, Jinjing Wang   +5 more
doaj   +1 more source

Nanotechnology‐Enhanced Approaches for Early Cancer Diagnosis

Nano Select, Volume 7, Issue 1, January 2026.
Conventional MRI and PET provide limited sensitivity and contrast for precise brain lesion detection. In contrast, radiolabeled nanoparticlebased PET imaging enables enhanced signal specificity and sensitivity. By integrating multifunctional nanoprobes, this platform improves multimodal imaging performance, allowing more accurate visualization of ...
Jongmoo Lee, Jiyu Kim, Eunhye Cho, Junyeop Jeong, Jayeon Song, Mikyung Kang   +5 more
wiley   +1 more source

From Genomic Fossils to Functional Elements: The Evolving Story of Pseudogenes

Advanced Genetics, Volume 6, Issue 4, December 2025.
This review begins with an introduction, summarizing the research background in pseudogene studies. It then contains three aspects: identification of pseudogenes, detailing their classification and features in metazoan genomes; functional pseudogenes, introducing their reactivation and regulation mechanisms; and pseudogenes’ contribution to species ...
Mengyao Sun, Yanni Ma, Jia Yu
wiley   +1 more source

Sagittal Craniosynostosis with Uncommon Anatomical Pathologies in a 56-Year-Old Male Cadaver

Case Reports in Pathology, 2019
Sagittal craniosynostosis (CS) is a pathologic condition that results in premature fusion of the sagittal suture, restricting the transverse growth of the skull leading in some cases to elevated intracranial pressure and neurodevelopmental delay.
Andrey Frolov, Craig Lawson, Joshua Olatunde, James T. Goodrich, John R. Martin III   +4 more
doaj   +1 more source

TLX1 translocation variants and enhancer hijacking influence clinical outcome in T‐cell acute lymphoblastic leukemia

HemaSphere, Volume 9, Issue 12, December 2025.
Abstract The T‐cell Leukemia Homeobox 1 (TLX1) oncogene is frequently deregulated in T‐cell acute lymphoblastic leukemia (T‐ALL) and T‐cell lymphoblastic lymphoma (T‐LBL). In most instances, TLX1 overexpression results from its juxtaposition with a T‐cell receptor (TCR) locus caused by interchromosomal translocations.
Estelle Balducci, Thomas Steimlé, Agata Cieslak, Guillaume Charbonnier, Antoine Pinton, Mathieu Simonin, Charlotte Smith, Valentine Louis, Mélanie Féroul, Manon Delafoy, Sophie Kaltenbach, Audrey Bidet, Béatrice Grange, Lauren Rigollet, Patrick Villarese, Aurore Touzart, Hervé Dombret, André Baruchel, Nicolas Boissel, Vahid Asnafi   +19 more
wiley   +1 more source

The Fate of the Tumor in the Hands of Microenvironment: Role of TAMs and mTOR Pathway

Mediators of Inflammation, 2016
Since 2000, written with elegance and accuracy, Hanahan and Weinberg have proposed six major hallmarks of cancer and, together, they provide great advances to the understanding of tumoral biology.
Danilo Figueiredo Soave, Marina Pacheco Miguel, Fernanda Dias Tomé, Liliana Borges de Menezes, Patrícia Resende Alo Nagib, Mara Rúbia Nunes Celes   +5 more
doaj   +1 more source

Multiple Myeloma in Young Adults—Insights From a Tertiary Care Cancer Centre in India

eJHaem, Volume 6, Issue 6, December 2025.
ABSTRACT Background Multiple myeloma (MM) is primarily a disease of the elderly; data on young patients are limited. Aim To evaluate the clinical characteristics and outcomes of MM patients aged ≤$ \le $ 40 years. Methods We retrospectively analyzed newly diagnosed MM patients aged ≤ 40 years between 2013 and 2021.
George John, Sumeet Mirgh, Sachin Punatar, Nishant Jindal, Lingaraj Nayak, Akanksha Chichra, Alok Shetty, Anant Gokarn, Sweta Rajpal, Nikhil Patkar, Gaurav Chatterjee, Dhanalaxmi Shetty, Hemani Jain, Kinjalka Ghosh, Prashant Tembhare, Hasmukh Jain, Akash Pawar, Sumeet Gujral, Papagudi Subramaniam, Manju Sengar, Navin Khattry, Bhausaheb Bagal   +21 more
wiley   +1 more source