Results 31 to 40 of about 28,464 (119)

Epigenetic modifications in early stage lung cancer: pathogenesis, biomarkers, and early diagnosis

MedComm, Volume 6, Issue 3, March 2025.
Epigenetic changes like DNA methylation and histone modifications, key from atypical adenomatous hyperplasia to stage I lung cancer, precede genetic mutations and contribute to tissue dysplasia. Along with mRNA, noncoding RNA, and tumor microenvironment regulation, these markers, enhanced by liquid biopsy, are promising for early lung cancer diagnosis.
Lingfeng Bi, Xin Wang, Jiayi Li, Weimin Li, Zhoufeng Wang   +4 more
wiley   +1 more source

Liver Metastasis in Cancer: Molecular Mechanisms and Management

MedComm, Volume 6, Issue 3, March 2025.
This review focuses on the molecular mechanisms and clinical management of tumor liver metastasis. Liver metastasis is a primary manifestation of the aggressive dissemination of several extrahepatic tumors. Many risk factors, such as individual genetic background, liver diseases, diet, trauma, and medication, may accelerate this process.
Wenchao Xu, Jia Xu, Jianzhou Liu, Nanzhou Wang, Li Zhou, Junchao Guo   +5 more
wiley   +1 more source

MASH as an emerging cause of hepatocellular carcinoma: current knowledge and future perspectives

Molecular Oncology, Volume 19, Issue 2, Page 275-294, February 2025.
Metabolic dysfunction‐associated steatohepatitis is emerging as a leading cause of hepatocellular carcinoma in individuals whose lifestyle and dietary habits promote a positive energy balance. Here, we reviewed the role of free fatty acids in mediating lipotoxicity and its implications for organellar stress and genome alteration in hepatocytes ...
Michael Karin, Ju Youn Kim
wiley   +1 more source

Role of the Extracellular Matrix in Cancer: Insights into Tumor Progression and Therapy

Advanced Therapeutics, Volume 8, Issue 2, February 2025.
The extracellular matrix (ECM) is pivotal in cancer progression, influencing tumor growth, metastasis, and therapy resistance. This paper explores ECM remodeling, highlighting components like collagens and proteoglycans, their impact on immune evasion, and emerging therapies targeting ECM mechanics and composition.
Nimeet Desai, Deepak Sahel, Bhakti Kubal, Humzah Postwala, Yesha Shah, Vivek P Chavda, Clara Fernandes, Dharmendra K. Khatri, Lalitkumar K. Vora   +8 more
wiley   +1 more source

Metastatic brain tumors: from development to cutting‐edge treatment

MedComm, Volume 6, Issue 1, January 2025.
This abstract briefly reviews the diagnosis and treatment of brain metastases from lung cancer and breast cancer, the progress of artificial intelligence and multiomics. Importantly, we focus on the pathogenesis of brain metastases and the tumor microenvironment to seek treatment strategies.
Guilong Tanzhu, Liu Chen, Jiaoyang Ning, Wenxiang Xue, Ce Wang, Gang Xiao, Jie Yang, Rongrong Zhou   +7 more
wiley   +1 more source

Expression of ACE2 and a viral virulence-regulating factor CCN family member 1 in human iPSC-derived neural cells: implications for COVID-19-related CNS disorders

Inflammation and Regeneration, 2020
It has been reported that coronavirus disease 2019 (COVID-19) causes not only pneumonia but also systemic inflammations including central nervous system (CNS) disorders.
Yoshitaka Kase, Hideyuki Okano
doaj   +1 more source

Analysis of clinicopathological and molecular features of crawling-type gastric adenocarcinoma

Diagnostic Pathology, 2020
Background Crawling-type adenocarcinoma (CRA) is an important gastric cancer (GC) subtype that exhibits a specific histological pattern and has characteristic clinicopathological findings.
Yasuko Fujita, Noriyuki Uesugi, Ryo Sugimoto, Makoto Eizuka, Yosuke Toya, Risaburo Akasaka, Takayuki Matsumoto, Tamotsu Sugai   +7 more
doaj   +1 more source

Therapeutic potential of Parabacteroides distasonis in gastrointestinal and hepatic disease

MedComm, Volume 5, Issue 12, December 2024.
This review illustrate the metabolic network medicated by Parabacteroides distasonis and its role and action mechanism in gastrointestinal and hepatic disease. The natural components affecting Parabacteroides distasonis was summarized, which show the therapeutic potential for gastrointestinal and hepatic diseases. Abstract Increasing evidences indicate
Jingyi Duan, Qinmei Li, Yan Cheng, Weifeng Zhu, Hongning Liu, Fei Li   +5 more
wiley   +1 more source

Ginsenoside Rg1: A Neuroprotective Natural Dammarane‐Type Triterpenoid Saponin With Anti‐Depressive Properties

CNS Neuroscience &Therapeutics, Volume 30, Issue 12, December 2024.
Rg1 exhibits antidepressant effects through diverse mechanisms, such as anti‐inflammation, synaptic protection, neurogenesis promotion, brain‐derived neurotrophic factor release, enhancement of astrocyte gap junction function, and regulation of hypothalamic–pituitary–adrenal axis and antioxidative stress. Experimental studies validate Rg1's efficacy in
Dong Han, Zheng Zhao, Tinghui Mao, Man Gao, Xue Yang, Yan Gao   +5 more
wiley   +1 more source

Prostate Cancer: A Review of Genetics, Current Biomarkers and Personalised Treatments

Cancer Reports, Volume 7, Issue 10, October 2024.
ABSTRACT Background Prostate cancer is the second leading cause of cancer deaths in men, second only to lung cancer. Despite this, diagnosis and prognosis methods remain limited, with effective treatments being few and far between. Traditionally, prostate cancer is initially tested for through a prostate serum antigen (PSA) test and a digital rectum ...
Trevor K. Wilson, Oliver T. Zishiri
wiley   +1 more source