Results 41 to 50 of about 49,770 (119)

The influence of 2- chlorodeoxyadenosine in combination with tumour necrosis factor-α or its mutein on murine leukaemias L1210 and P388

Mediators of Inflammation, 1995
We investigated the influence of 2-chlorodeoxyadenosine (2-CdA) in combination with tumour necrosis factor-α (TNFα) or its mutein VI, which differs from the native molecule by N-terminal amino acid composition, on the survival time of mice inoculated ...
J. Góra-Tybor, K. Warzocha, T. Robak
doaj   +1 more source

A rare case of neuroendocrine cell tumor mixed with a mucinous component in the ampulla of Vater

Diagnostic Pathology
Background A rare case of neuroendocrine cell tumor (NET) having both conventional and mucinous components was reported. Mucinous NET is rarely encountered in the pathological diagnosis of gastrointestinal (GI) tumors.
Tamotus Sugai, Noriyuki Uesugi, Masamichi Suzuki, Nobuyasu Suzuki, Michitaka Honda, Tsuyoshi Abe, Naoki Yanagawa   +6 more
doaj   +1 more source

Interactions between Neutrophils, Th17 Cells, and Chemokines during the Initiation of Experimental Model of Multiple Sclerosis

Mediators of Inflammation, 2014
Experimental autoimmune encephalomyelitis (EAE) is an animal model of multiple sclerosis (MS) in which activated T cell and neutrophil interactions lead to neuroinflammation.
Dagmara Weronika Wojkowska, Piotr Szpakowski, Dominika Ksiazek-Winiarek, Marcin Leszczynski, Andrzej Glabinski   +4 more
doaj   +1 more source

Parkinson's Disease and Cancer: Mechanistic Insights and Therapeutic Opportunities From Cancer Neuroscience

MedComm – Oncology, Volume 4, Issue 4, December 2025.
Parkinson's disease (PD) and glioma are neurological disorders with distinct and even opposing mechanisms: α‐synuclein deposition and neuronal loss in PD versus glial cell malignancy in glioma. Despite these differences, their contrasting pathologies highlight multiple therapeutic targets.
Tianli Pan, Lin Yuan, Ruoyang Zhao, Liting Lu, Yinghao Zhi, Yuying Li, Min Wu, Yongye Huang   +7 more
wiley   +1 more source

Development of crizotinib-associated renal cyst in a non-small cell lung cancer patient with ALK fusion: a case report and review of the literature

Diagnostic Pathology
Background Crizotinib, an oral first-generation tyrosine kinase inhibitor (TKI), is superior to systemic chemotherapy for the treatment of non-small cell lung cancer (NSCLC) with positive rearrangement of anaplastic lymphoma kinase (ALK).
Peng Zhang, JiaHua Xu, Qing Wu, Jianxin Qian, Song Wang   +4 more
doaj   +1 more source

Susceptibility of lung epithelium to neutrophil elastase: protection by native inhibitors

Mediators of Inflammation, 1997
The development of emphysema is thought to be due to an imbalance of proteases (especially neutrophil elastase [NE]) and antiproteases with loosening of the respiratory epithelium as an early event.
L. Bingle, R. J. Richards, B. Fox, L. Masek, A. Guz, T. D. Tetley   +5 more
doaj   +1 more source

Leveraging genomic diagnostics for prognostics and therapeutics in pediatric acute leukemia

HemaSphere, Volume 9, Issue 11, November 2025.
Abstract Advancements in the rapidity, cost efficacy, and sensitivity of next‐generation sequencing (NGS) have facilitated molecular risk stratification and precision medicine‐based treatment for pediatric leukemia. The benefit of uniform cytomolecular analyses for clinical trial risk assignment is clear.
Haley Newman, Derek Wong, Jinhua Wu, Jeffrey Schubert, Netta Golenberg, Natali Naveh, Maha Patel, Feng Xu, Sarah Charles, Jiani Chen, Elizabeth H. Denenberg, Elizabeth A. Fanning, Daniel Gallo, Tammy Luke, Morgan Thomas, Kajia Cao, Ada J. S. Chan, Munashe Holloman, Zhiqian Fan, Weixuan Fu, Stephen P. Hunger, Suzanne P. MacFarland, Kathrin M. Bernt, Lea F. Surrey, Minjie Luo, Gerald B. Wertheim, Marilyn M. Li, Sarah K. Tasian, Yiming Zhong   +28 more
wiley   +1 more source

Epiphyseal Primary Diffuse Large B-Cell Lymphoma of Bone

Case Reports in Pathology, 2018
Primary lymphoma of bone (PLB) confined to the epiphysis has only been described in four other patients. Due to the rarity of this entity, diagnosis has often been delayed, leading to mismanagement with adverse clinical consequences.
Shachar Kenan, Leonard Kahn, Morris Edelman, Arlene Redner, Samuel Kenan   +4 more
doaj   +1 more source

SOX10, MITF, and microRNAs: Decoding their interplay in regulating melanoma plasticity

International Journal of Cancer, Volume 157, Issue 7, Page 1277-1293, 1 October 2025.
Abstract Recent studies show that the dysregulation of the transcription factor SOX10 is essential for the development and progression of melanoma. MicroRNAs (miRNAs) can regulate the expression of transcription factors at the post‐transcriptional level. The interactions between SOX10 and its targeting miRNAs form network motifs such as feedforward and
Xin Lai, Chunyan Luan, Zhesi Zhang, Anja Wessely, Markus V. Heppt, Carola Berking, Julio Vera   +6 more
wiley   +1 more source

Sequences of acetyl CoA carboxylase promoter for tumour necrosis factor action

Mediators of Inflammation, 1993
Tumour necrosis factor (TNF) inhibits the accumulation of acetyl CoA carboxylase (ACC) mRNA by decreasing the rate of ACC gene transcription. The ACC mRNA species found in 30A5 cells are generated from promoter II and TNF inhibits the accumulation of ...
Keerang Park, Michael E. Pape, Ki-Han Kim   +2 more
doaj   +1 more source