Results 201 to 210 of about 107,123 (321)

Characteristics and Outcomes of Patients With Dedifferentiated Liposarcoma in a US Community Setting

Cancer Medicine, Volume 15, Issue 6, June 2026.
US community oncology patients with dedifferentiated liposarcoma have heterogeneous profiles, treatments, and outcomes. The poor survival rates in this population suggest an unmet need for better therapeutics. ABSTRACT Introduction Clinical characteristics and outcomes of patients treated for dedifferentiated liposarcoma (DDLPS) at community oncology ...
James E. Butrynski, Bal Nepal, Chenxiao Hu, Jinhong Guo, Jennifer Han, Lisa Herms, Alyssa B. Klein, Stephen Stanhope, Elizabeth L. Stanley, Karen Todoroff, Paul Conkling   +10 more
wiley   +1 more source

Ginsenoside Rb1 alleviates overtraining-induced oxidative stress in mouse liver by stimulating mitophagy via Nrf2 pathway. [PDF]

Front Nutr
Lu J, Xu R, Gao Y, Zong L, Wang D, Li J.
europepmc   +1 more source

Synergistic Antitumor Activity of HAT Inhibitor A485 and XPO1 Inhibitor KPT8602 in Multiple Myeloma

Cancer Medicine, Volume 15, Issue 6, June 2026.
ABSTRACT Background Multiple myeloma (MM) remains the second most common hematologic malignancy, necessitating the identification of novel therapeutic targets. MM is characterized by a distinct epigenetic landscape driven by aberrant chromatin activation and super‐enhancer addiction.
Hong Xu, Wenqi Wu, Yanan Jiang, Jinhuan Wang, Yixin Zhai, Zhigang Zhao   +5 more
wiley   +1 more source

TLR4 and RB1 as the Identified Lactate-Related Genes to Predict the Diagnostic Performance, Gene Regulatory Network, and Targeting Drugs in Depression. [PDF]

Hum Mutat
Ding F, Chen J, Wu J, Bian Q.
europepmc   +1 more source

Cervical Skip Metastases and Extensive Central Venous Thrombosis as the Initial Presentation of High‐Grade Prostate Adenocarcinoma With Discordant PI‐RADS 3 Findings: A Case Report and Diagnostic Challenge

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Prostate cancer can initially present with cervical lymph node “skip” metastases and extensive central venous thrombosis, without pelvic or bone involvement. A PI‐RADS 3 lesion on mpMRI does not exclude high‐grade (Gleason 5 + 5 = 10) disease. Unexplained thrombosis in elderly men warrants prostate cancer investigation.
Yuchun Luo, Benhui Lai, Juncheng Huang
wiley   +1 more source

Germline BRCA2 mutations foster resistance to CDK4/6 inhibitors in breast cancer. [PDF]

NPJ Precis Oncol
Bolini L, Naulin F, Johnson N, Galluzzi L.   +3 more
europepmc   +1 more source

Quantification of Cells with Modifications Relating to the RB1 Pathway

The retinoblastoma tumor suppressor (RB1) is a vital tumor suppressor gene. It prevents the cell from transitioning to the S phase from G phase by inhibiting E2F activity which limits cell proliferation and facilitates a stable exit from the cell cycle ...
Yu, Jeanmyung, \u2725
core  

Patients With Stage III PLCNEC Advocated for Radiotherapy Combined With Chemotherapy While With Stage IV Focus on Individualized Management: Evidence From SEER

Cancer Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background PLCNEC is a rare and highly aggressive lung cancer with a poor prognosis. Multimodal therapy, primarily chemotherapy‐based, is the standard for advanced PLCNEC, but the role of radiotherapy remains unclear. Methods We analyzed 1086 PLCNEC patients receiving chemotherapy from the Surveillance, Epidemiology, and End Results (SEER ...
Yuze Zhao, Guantong Liu, Haitao Li, Yu Li, Ting Lin, Zefeng Xie   +5 more
wiley   +1 more source

LDHC4 drives lung adenocarcinoma progression by inducing lactylation of RB1 at lysine 900 to disrupt the RB1-E2F1 complex. [PDF]

J Transl Med
Peng W, Lin Z, Sun C, Lin L, Cui Z, Lin D.   +5 more
europepmc   +1 more source

MITF Gain‐of‐Function Mutation in Metastatic Prostate Cancer: A Rare Finding With Potential Therapeutic Significance

Cancer Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background Prostate cancer is the most common non‐cutaneous malignancy in men and remains a leading cause of cancer‐related mortality, particularly in aggressive variants. These tumors are usually associated with alterations in TP53, RB1, and PTEN.
Paul J. Pecorin, Nyembezi Dhliwayo, Matthew Demetrious, Ludimila Cavalcante, Veronica Rodriguez‐Bravo, Josep Domingo Domenech, Thomas Westbrook   +6 more
wiley   +1 more source