Results 51 to 60 of about 20,257 (224)

Cbl downregulation increases RBP4 expression in adipocytes of female mice [PDF]

Journal of Endocrinology, 2018
Obesity leads to adipose tissue dysfunction, insulin resistance and diabetes. Adipose tissue produces adipokines that contribute to regulate insulin sensitivity. In turn, insulin stimulates the production and release of some adipokines. Casitas-b-lymphoma proteins (c-Cbl, Cbl-b and Cbl3) are intracellular adaptor signalling proteins that are rapidly ...
Ameen, Gulizar Issa, Mora Fayos, Sílvia
openaire   +3 more sources

RBP4 Is Associated With Insulin Resistance in Hyperuricemia-Induced Rats and Patients With Hyperuricemia

Frontiers in Endocrinology, 2021
Objective Hyperuricemia (HUA) is strongly associated with abnormal glucose metabolism and insulin resistance (IR). However, the precise molecular mechanism of HUA-induced IR is still unclear.
Chan Liu, Xiaoting Zhou, M. Ye, Xiang-qing Xu, Yu-wei Zhang, Hong Liu, Xian-Zhe Huang   +6 more
semanticscholar   +1 more source

Large Benefit from Simple Things: High-Dose Vitamin A Improves RBP4-Related Retinal Dystrophy

International Journal of Molecular Sciences, 2022
Inherited retinal diseases (IRD) are a group of heterogeneous disorders, most of which lead to blindness with limited therapeutic options. Pathogenic variants in RBP4, coding for a major blood carrier of retinol, retinol-binding protein 4, are ...
V. Smirnov, Baptiste Wilmet, M. Nassisi, C. Condroyer, A. Antonio, Camille Andrieu, Céline Devisme, Serge Sancho, J. Sahel, C. Zeitz, I. Audo   +10 more
semanticscholar   +1 more source

Involvement of RBP4 in all-trans retinoic acid induced cleft palate

Molecular Medicine Reports, 2017
The current study was designed to elucidate the mechanism of retinol binding protein 4 (RBP4) in cleft palate induced by all‑trans retinoic acid (atRA). To establish a cleft palate model in C57BL/6J mice, pregnant mice were administered atRA (100 mg/kg) by gavage at the tenth embryonic stage (E10.0).
Shiyi Dong, Yadong Zhang, Hongzhang Huang   +2 more
openalex   +5 more sources

Association of urinary RBP4 with insulin resistance, inflammation, and microalbuminuria [PDF]

European Journal of Endocrinology, 2014
ObjectiveSerum concentrations of retinol-binding protein 4 (RBP4) are elevated in type 2 diabetes and associated with the severity of insulin resistance; however, there are few data about the relationship between urinary RBP4 levels and metabolic parameters.
Se Eun, Park, Nam Seok, Lee, Ji Woo, Park, Eun-Jung, Rhee, Won-Young, Lee, Ki-Won, Oh, Sung-Woo, Park, Cheol-Young, Park, Byung-Soo, Youn   +8 more
openaire   +2 more sources

Down-regulation of RBP4 indicates a poor prognosis and correlates with immune cell infiltration in hepatocellular carcinoma

Bioscience Reports, 2021
Recent research has indicated that metabolically related genes play crucial roles in the pathogenesis of hepatocellular carcinoma (HCC). We evaluated the associations between novel biomarkers and retinol-binding protein 4 (RBP4) for predicting clinical ...
Mingxing Li, Zhihui Wang, Lixu Zhu, Yifang I. Shui, Shuijun Zhang, Wenzhi Guo   +5 more
semanticscholar   +1 more source

Elevated Serum Levels of Retinol-Binding Protein 4 Are Associated with Breast Cancer Risk: A Case-Control Study. [PDF]

PLoS ONE, 2016
Retinol binding protein 4 (RBP4) is a recently identified adipokine that is elevated in patients with obesity or type 2 diabetes. A growing body of research has shown that RBP4 is associated with several types of cancer.
Congcong Jiao, Lianhua Cui, Aiguo Ma, Na Li, Hongzong Si   +4 more
doaj   +1 more source

Correlation of serum RBP4 level with oxidative stress and unstable carotid plaque in patients with cerebral infarction

Translational Neuroscience, 2022
Objectives This study aimed to investigate the changes in serum levels of retinol-binding protein 4 (RBP4) with cerebral infarction, relationship of RBP4 with oxidative stress and carotid atherosclerosis, and its possible role in cerebral infarction ...
Qingqing Wang, Shan Tian, Dahai Xiao, Ruotong Zhao, Xiao-Xuan Zhang, Zhijie Dou, Chengbo Li, Zheng Ma   +7 more
semanticscholar   +1 more source

The Camp-HMGA1-RBP4 System [PDF]

BMC Biology, 2009
Abstract Background We previously showed that mice lacking the high mobility group A1 gene (Hmga1-knockout mice) developed a type 2-like diabetic phenotype, in which cell-surface insulin receptors were dramatically reduced (below 10% of those in the controls) in the major targets of insulin action, and glucose ...
Chiefari E., Paonessa F., Iiritano S, Le Pera I., PALMIERI, DARIO, Brunetti G., Lupo A., Colantuoni V., Foti D., Gulletta E., De Sarro G., FUSCO, ALFREDO, Brunetti A.   +12 more
openaire   +6 more sources

Evaluating Serum RBP4 as an Auxiliary Biomarker for CKDu Diagnosis

Kidney and Dialysis, 2022
Background: A chronic interstitial disease, chronic kidney disease of uncertain etiology (CKDu), has emerged as a notable contributor to the CKD burden in rural Sri Lanka. Most therapeutic and diagnostic approaches to CKD focus on glomerular diseases, and thus are not fully applicable to CKDu.
Hannah L. F. Swa, Buddhi N. T. Fernando, Shakila Premarathna, Asfa Alli-Shaik, Zeid Badurdeen, Jayantha Gunarathna, Nishantha Nanayakkara   +6 more
openaire   +2 more sources