Results 31 to 40 of about 21,878 (196)

Altering retinol binding protein 4 levels in hepatitis C: Inflammation and steatosis matter

Virulence, 2020
Both hepatitis C virus (HCV) infection and retinol-binding protein 4 (RBP4) might contribute to insulin resistance (IR), how RBP4 links to IR in HCV infection remain elusive.
Ming-Ling Chang, Wei-Ting Chen, Jing-Hong Hu, Shiang-Chi Chen, Po-Wen Gu, Rong-Nan Chien   +5 more
doaj   +1 more source

Mapping of the extracellular RBP4 ligand binding domain on the RBPR2 receptor for Vitamin A transport

Frontiers in Cell and Developmental Biology, 2023
The distribution of dietary vitamin A/all-trans retinol/ROL throughout the body is critical for maintaining retinoid function in peripheral tissues and for retinoid delivery to the eye in the support of visual function.
Rakesh Radhakrishnan, Matthias Leung, Ashish K. Solanki, Glenn P. Lobo, Glenn P. Lobo, Glenn P. Lobo   +5 more
doaj   +1 more source

Retinol-binding protein 4 in polycystic ovary syndrome--association with steroid hormones and response to pioglitazone treatment [PDF]

, 2009
CONTEXT: Polycystic ovary syndrome (PCOS) is frequently associated with insulin resistance. OBJECTIVE: The aim of the study was to investigate a putative role of the adipokines retinol-binding protein 4 (RBP4), adiponectin, and visfatin in a cohort of ...
Aigner, Elmar, Patsch, Wolfgang, Bachofner, Nora, Klein, Kerstin, Datz, Christian, Hohla, Florian, De Geyter, Christian   +6 more
core   +1 more source

Plasma RBP4 Level in Association with Body Composition, Metabolic Profile, STRA6 and RBP4 Gene Polymorphisms in Obese Romanian Children.

Diabetes, metabolic syndrome and obesity : targets and therapy, 2020
Pediatric obesity continues to remain a serious health concern which has significantly increased the morbidity risk in adulthood. Recent studies have analyzed the impact of the two adipokines, RBP4 (retinol binding protein 4) and STRA6 (stimulated by retinoic acid 6) in pediatric obese subjects with contradictory results.An observational study was ...
Boaghi,Anastasia, Pop,Raluca-Monica, Vasilache,Simona Loredana, Banescu,Claudia, Hutanu,Adina, Marginean,Oana Cristina, Pascanu,Ionela Maria   +6 more
openaire   +4 more sources

Elevated Serum Levels of Retinol-Binding Protein 4 Are Associated with Breast Cancer Risk: A Case-Control Study. [PDF]

PLoS ONE, 2016
Retinol binding protein 4 (RBP4) is a recently identified adipokine that is elevated in patients with obesity or type 2 diabetes. A growing body of research has shown that RBP4 is associated with several types of cancer.
Congcong Jiao, Lianhua Cui, Aiguo Ma, Na Li, Hongzong Si   +4 more
doaj   +1 more source

Retinol-binding Protein 4 and Diabetes Mellitus: A Review on Current Understanding and Clinical Importance [PDF]

Journal of Clinical and Diagnostic Research
The Retinol-binding Protein 4 (RBP4) has evolved as an important metabolic signal associated with insulin resistance and diabetes mellitus. Research shows that RBP4 increases early in metabolic stress and thus a potential marker for identifying ...
Roshan Takhelmayum, KM Tullanithi, Robby Kumar, Jyoti E John   +3 more
doaj   +1 more source

Transgenic Mice Over-Expressing RBP4 Have RBP4-Dependent and Light-Independent Retinal Degeneration

Investigative Opthalmology & Visual Science, 2017
Transgenic mice overexpressing serum retinol-binding protein (RBP4-Tg) develop progressive retinal degeneration, characterized by microglia activation, yet the precise mechanisms underlying retinal degeneration are unclear. Previous studies showed RBP4-Tg mice have normal ocular retinoid levels, suggesting that degeneration is independent of the ...
Du, Mei, Phelps, Eric, Balangue, Michael J., Dockins, Aaron, Moiseyev, Gennadiy, Shin, Younghwa, Kane, Shelley, Otalora, Laura, Ma, Jian-Xing, Farjo, Rafal, Farjo, Krysten M.   +10 more
openaire   +2 more sources

Decreased Retinol Binding Protein 4 Concentrations are Associated With Cholesterol Gallstone Disease

Journal of the Formosan Medical Association, 2010
Circulating retinol binding protein 4 (RBP4) is associated with a variety of obesity-related diseases. This study investigated whether there were aberrant concentrations of RBP4 in cholesterol gallstone disease.
Shen-Nien Wang, Yao-Tsung Yeh, Sen-Teh Wang, Yi-Ling Chen, Shih-Chang Chuang, Chen-Guo Ker, King-Teh Lee   +6 more
doaj   +1 more source

A Functional Binding Domain in the Rbpr2 Receptor Is Required for Vitamin A Transport, Ocular Retinoid Homeostasis, and Photoreceptor Cell Survival in Zebrafish

Cells, 2020
Dietary vitamin A/all-trans retinol/ROL plays a critical role in human vision. ROL circulates bound to the plasma retinol-binding protein (RBP4) as RBP4-ROL. In the eye, the STRA6 membrane receptor binds to circulatory RBP4 and internalizes ROL. STRA6 is,
Ashish K. Solanki, Altaf A. Kondkar, Joseph Fogerty, Yanhui Su, Seok-Hyung Kim, Joshua H. Lipschutz, Deepak Nihalani, Brian D. Perkins, Glenn P. Lobo   +8 more
doaj   +1 more source

Comparative pharmacokinetics and pharmacodynamics of the advanced Retinol-Binding Protein 4 antagonist in dog and cynomolgus monkey.

PLoS ONE, 2020
Accumulation of lipofuscin bisretinoids in the retina contributes to pathogenesis of macular degeneration. Retinol-Binding Protein 4 (RBP4) antagonists reduce serum retinol concentrations thus partially reducing retinol delivery to the retina which ...
Boglarka Racz, Andras Varadi, Paul G Pearson, Konstantin Petrukhin   +3 more
doaj   +1 more source