Results 11 to 20 of about 21,878 (196)
Adipokine RBP4 drives ovarian cancer cell migration [PDF]
Journal of Ovarian Research, 2018 Background Obesity has been linked to several types of cancers including ovarian cancer. Retinol binding protein 4 (RBP4) is an adipokine that drives the development of hyperinsulinemia and type II diabetes in obesity patients and animals. Previously, we
Yanyan Wang, Yilin Wang, Zhenyu Zhang
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Interleukin-1β downregulates RBP4 secretion in human adipocytes. [PDF]
PLoS ONE, 2013 AIMS/HYPOTHESIS: The excessive accumulation of adipose tissue in the obese state is linked to an altered secretion profile of adipocytes, chronic low-grade inflammation and metabolic complications.
Primoz Kotnik +3 more
doaj +5 more sources
The Hepatokine RBP4 Links Metabolic Diseases to Articular Inflammation
AntioxidantsObjectives: This study investigates the role of retinol binding protein 4 (RBP4) in an articular context. RBP4, a vitamin A transporter, is linked to various metabolic diseases.
Andrés Pazos-Pérez +10 more
doaj +4 more sources
BiomedicinesBackground: The protein that binds to retinol 4 (RBP4), is a lipocalin-family protein, secreted primarily by the adipose tissue and the liver, and has also been reported to be produced by other tissues, including the kidney. This protein mediates the transport of vitamin A (retinol) in the circulation, bound to a transporter protein, transthyretin.
Nieto-Bona MP +2 more
europepmc +4 more sources
The association of RBP4 with chronic kidney diseases in southern Chinese population [PDF]
Frontiers in EndocrinologyBackgroundRetinol binding protein 4 (RBP4), as a novel adipokine, has been proven to be highly related to insulin resistance, obesity, diabetes, hypertension, hyperuricemia and other metabolic diseases, which are all risk factors for chronic kidney ...
Tong Chen +16 more
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RBP4: a controversial adipokine [PDF]
European Journal of Endocrinology, 2011 Adipose tissue is an endocrine organ secreting biologically active factors called adipokines that act on both local and distant tissues. Adipokines have an important role in the development of obesity-related comorbidities not only in adults but also in children and adolescents.
Primoz, Kotnik +2 more
openaire +3 more sources
Hepatocytes Are the Principal Source of Circulating RBP4 in Mice [PDF]
Diabetes, 2016 RBP4 is produced mainly by hepatocytes. In type 2 diabetes and obesity, circulating RBP4 is increased and may act systemically to cause insulin resistance and glucose intolerance. Observations that adipocyte RBP4 mRNA increases in parallel with circulating RBP4 in these conditions, whereas liver RBP4 mRNA does not, led to a widely held hypothesis that ...
Thompson, Spencer +9 more
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RBP4 variants are significantly associated with plasma RBP4 levels and hypertriglyceridemia risk in Chinese Hans[S] [PDF]
Journal of Lipid Research, 2009 We previously found that plasma RBP4 levels were strongly associated with metabolic syndrome components. This study aimed to determine whether RBP4 variants are associated with the metabolic syndrome components and plasma RBP4 levels, and to investigate ...
Ying Wu +6 more
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Evaluating Serum RBP4 as an Auxiliary Biomarker for CKDu Diagnosis
Kidney and Dialysis, 2022 Background: A chronic interstitial disease, chronic kidney disease of uncertain etiology (CKDu), has emerged as a notable contributor to the CKD burden in rural Sri Lanka. Most therapeutic and diagnostic approaches to CKD focus on glomerular diseases, and thus are not fully applicable to CKDu.
Hannah L. F. Swa +6 more
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Isoforms of Retinol binding protein 4 (RBP4) are increased in chronic diseases of the kidney but not of the liver [PDF]
Lipids in Health and Disease, 2008 Background The levels of retinol-binding protein 4 (RBP4) – the carrier protein for Vitamin A in plasma – are tightly regulated under healthy circumstances.
Weickert Martin O +10 more
doaj +2 more sources