Results 21 to 30 of about 21,878 (196)

Cbl downregulation increases RBP4 expression in adipocytes of female mice [PDF]

Journal of Endocrinology, 2018
Obesity leads to adipose tissue dysfunction, insulin resistance and diabetes. Adipose tissue produces adipokines that contribute to regulate insulin sensitivity. In turn, insulin stimulates the production and release of some adipokines. Casitas-b-lymphoma proteins (c-Cbl, Cbl-b and Cbl3) are intracellular adaptor signalling proteins that are rapidly ...
Ameen, Gulizar Issa, Mora Fayos, Sílvia
core   +7 more sources

Liver-secreted RBP4 does not impair glucose homeostasis in mice [PDF]

Journal of Biological Chemistry, 2018
Retinol-binding protein 4 (RBP4) is the major transport protein for retinol in blood. Recent evidence from genetic mouse models shows that circulating RBP4 derives exclusively from hepatocytes. Because RBP4 is elevated in obesity and associates with the development of glucose intolerance and insulin resistance, we tested whether a liver-specific ...
Fedders, Ronja, Muenzner, Matthias, Weber, Pamela, Sommerfeld, Manuela, Knauer, Miriam, Kedziora, Sarah, Kast, Naomi, Heidenreich, Steffi, Raila, Jens (Prof. Dr.), Weger, Stefan, Henze, Andrea (Dr.), Schupp, Michael   +11 more
openaire   +3 more sources

An RBP4 promoter polymorphism increases risk of type 2 diabetes [PDF]

Diabetologia, 2008
Retinol-binding protein 4 (RBP4), originally known for retinol transport, was recently identified as an adipokine affecting insulin resistance. The RBP4 -803GA promoter polymorphism influences binding of hepatic nuclear factor 1alpha and is associated with type 2 diabetes in case-control studies.
van der Hoek, M, Dehghan, Abbas, Zillikens, M.C., Hofman, Bert, Witteman, JCM, Sijbrands, E.J.G.   +5 more
openaire   +4 more sources

Clinical, genetic and biochemical signatures of RBP4-related ocular malformations [PDF]

, 2023
Background: The retinoic acid (RA) pathway plays a crucial role in both eye morphogenesis and the visual cycle. Individuals with mono- and bi-allelic pathogenic variants in RBP4, encoding a serum retinol specific transporter, display variable ocular ...
Whalen, Sandra, Perthus, Isabelle, Plaisancié, Julie, Marzin, Pauline, Chesneau, Bertrand, Rodriguez, Diana, Holt, Richard, Audebert-Bellanger, Séverine, Bax, Dorine, Ragge, Nicola K., Grotto, Sarah, Chassaing, Nicolas, Martinovic, Jelena   +12 more
core   +6 more sources

The Prognostic Role of IL-6 and RBP4 in Colorectal Cancer

Biomedicines
Background/Objectives: Colorectal cancer (CRC) is one of the leading causes of cancer-related mortality worldwide. Inflammation and metabolic dysregulation, particularly those related to obesity, have emerged as critical contributors to CRC progression.
Małgorzata Żulicka, Daria Piątkowska, Dariusz Grzanka, Klaudia Bonowicz, Dominika Jerka, Maciej Gagat, Paulina Antosik   +6 more
openaire   +4 more sources

RBP4-based multimarker score: A prognostic tool for adverse cardiovascular events in acute coronary syndrome patients

, 2023
 RBP4-based multimarker score: A prognostic tool for adverse cardiovascular events in acute coronary syndrome patients 
Bingqi Ye (16301312)
core   +1 more source

Rbp4-Gal4, a germline driver that activates in meiosis, reveals functions for VCP in spermatid development

, 2023
Valosin-containing protein (VCP) is a versatile and ubiquitously expressed AAA+ ATPase that regulates multiple stages of Drosophila spermatogenesis. While VCP has documented roles in mitotic spermatogonia and meiotic spermatocytes, it is also highly ...
Tyler J. Butsch (11602554), Alyssa E. Johnson (11602557), K. Adam Bohnert (11602560)   +2 more
core   +1 more source

The Effect of RBP4 on microRNA Expression Profiles in Porcine Granulosa Cells [PDF]

Animals, 2021
Retinol binding protein 4 (RBP4) is a transporter of vitamin A that is secreted mainly by hepatocytes and adipocytes. It affects diverse pathophysiological processes, such as obesity, insulin resistance, and cardiovascular diseases. MicroRNAs (miRNAs) have been reported to play indispensable roles in regulating various developmental processes via the ...
Yun Zhao, Jiahui Rao, Tong Qiu, Chunjin Li, Xu Zhou   +4 more
openaire   +3 more sources

The associations between retinol binding protein-4 and cardiometabolic profile: Intertwined-intricate relationship

Biomedical and Biotechnology Research Journal, 2020
Retinol binding protein-4 (RBP4) is a new adipokine synthesized by the liver and adipose tissue, and its secretion depends on retinol concentrations and reflects visceral fat mass.
Marwa Thaier Naji, Oula Mohamed Sami, Hala Aqeel Shams, May Hassan Abdul-Hadi, Hayder Mutter Al-Kuraishy, Ali Ismail Al-Gareeb, Naseer Abdul-Amer Al-Harchan   +6 more
doaj   +1 more source

Associations between retinol-binding protein 4 and cardiometabolic risk factors and subclinical atherosclerosis in recently postmenopausal women: cross-sectional analyses from the KEEPS study

Cardiovascular Diabetology, 2012
Background The published literature regarding the relationships between retinol-binding protein 4 (RBP4) and cardiometabolic risk factors and subclinical atherosclerosis is conflicting, likely due, in part, to limitations of frequently used RBP4 assays ...
Huang Gary, Wang Dan, Khan Unab I, Zeb Irfan, Manson JoAnn E, Miller Virginia, Hodis Howard N, Budoff Matthew J, Merriam George R, Harman Mitchell S, Brinton Eliot A, Cedars Marcelle I, Su Yali, Lobo Rogerio A, Naftolin Frederick, Santoro Nanette, Taylor Hugh S, Wildman Rachel P   +17 more
doaj   +1 more source