Stem Cell Reports, 2017 Summary: The transmembrane protein, STRA6, functions as a vitamin A transporter and a cytokine receptor when activated by vitamin A-bound serum retinol binding protein 4 (RBP4).
Liraz Levi, Matthew F Kalady, Noa Noy
exaly +3 more sources
STRA6 exerts oncogenic role in gastric tumorigenesis by acting as a crucial target of miR-873
Journal of Experimental and Clinical Cancer Research, 2019 Background Increasing evidence shows that stimulated by retinoic acid 6 (STRA6) participates in regulating multiple cancers. However, the biological roles of STRA6 in gastric cancer (GC) remain unknown.
Jian Xiao, Zekuan Xu, Li Yang
exaly +3 more sources
Vitamin A Transport Mechanism of the Multitransmembrane Cell-Surface Receptor STRA6
Membranes, 2015 Vitamin A has biological functions as diverse as sensing light for vision, regulating stem cell differentiation, maintaining epithelial integrity, promoting immune competency, regulating learning and memory, and acting as a key developmental morphogen ...
Riki Kawaguchi, Miki Kassai
exaly +3 more sources
Production of functional human vitamin A transporter/RBP receptor (STRA6) for structure determination. [PDF]
PLoS ONE, 2015 STRA6 is a plasma membrane protein that mediates the transport of vitamin A, or retinol, from plasma retinol binding protein (RBP) into the cell. Mutations in human STRA6 are associated with Matthew-Wood syndrome, which is characterized by severe ...
Conor J Breen +5 more
doaj +1 more source
Frontiers in Endocrinology, 2023 BackgroundBRAF mutation is one of the most common genetic alterations contributing to the initiation and progression of papillary thyroid carcinoma (PTC). However, the prognostic value of BRAF mutation for PTC is limited.
Weiman He +8 more
doaj +1 more source
To investigate the necessity of STRA6 upregulation in T cells during T cell immune responses. [PDF]
PLoS ONE, 2013 Our earlier study revealed that STRA6 (stimulated by retinoic acid gene 6) was up-regulated within 3 h of TCR stimulation. STRA6 is the high-affinity receptor for plasma retinol-binding protein (RBP) and mediates cellular vitamin A uptake.
Rafik Terra +10 more
doaj +1 more source
Retinol from hepatic stellate cells via STRA6 induces lipogenesis on hepatocytes during fibrosis
Cell & Bioscience, 2021 Background Hepatic stellate cells (HSCs) are activated in response to liver injury with TIF1γ-suppression, leading to liver fibrosis. Here, we examined the mechanism how reduction of TIF1γ in HSCs induces damage on hepatocytes and liver fibrosis.
Injoo Hwang +4 more
doaj +1 more source
Vitamin A transport and the transmembrane pore in the cell-surface receptor for plasma retinol binding protein. [PDF]
PLoS ONE, 2013 Vitamin A and its derivatives (retinoids) play diverse and crucial functions from embryogenesis to adulthood and are used as therapeutic agents in human medicine for eye and skin diseases, infections and cancer.
Ming Zhong +4 more
doaj +1 more source
Adaptive evolution of the STRA6 genes in mammalian. [PDF]
PLoS ONE, 2014 Stimulated by retinoic acid 6 (STRA6) is the receptor for retinol binding protein and is relevant for the transport of retinol to specific sites such as the eye.
Jianghong Wu +7 more
doaj +1 more source
Diabetes Aggravates Photoreceptor Pathologies in a Mouse Model for Ocular Vitamin A Deficiency
Antioxidants, 2022 Emerging evidence indicates that diabetes disturbs photoreceptor function and vitamin A homeostasis. However, the biochemical basis of this phenotype is not well established.
Srinivasagan Ramkumar +5 more
doaj +1 more source