Results 11 to 20 of about 2,199 (176)

Vitamin A deficiency attenuates cardiac rupture in Stra6-deficient hearts following ischemic injury [PDF]

Frontiers in Cardiovascular Medicine
BackgroundStimulated by retinoic acid gene 6 (STRA6) is a cell surface receptor that regulates cellular uptake of vitamin A metabolites and cardiac development.
Yannick Smolenski, Natali Froese, Paolo Galuppo, Christopher Werlein, Anna Gigina, Steven R. Talbot, Sergej Erschow, Dirk Wedekind, Robert Geffers, Norbert B. Ghyselinck, Heike Bähre, Jan C. Kamp, Jan C. Kamp, Lavinia Neubert, Lavinia Neubert, Melanie Ricke-Hoch, Johann Bauersachs, Christian Riehle   +17 more
doaj   +3 more sources

Crossing the Barrier: STRA6 in Epidermal Differentiation [PDF]

Journal of Investigative Dermatology, 2014
In this issue, Skazik et al. demonstrate that the STRA6 retinol transporter protein regulates the proliferation and differentiation of epidermal keratinocytes. In human organotypic three-dimensional skin and skin reconstitution models, depletion of STRA6 induced hyperproliferation-associated differentiation, resulting in epidermal expansion.
Laursen, Kristian B., Gudas, Lorraine J.
openaire   +4 more sources

First implication ofSTRA6mutations in isolated anophthalmia, microphthalmia, and coloboma: A new dimension to theSTRA6phenotype [PDF]

Human Mutation, 2011
Microphthalmia, anophthalmia, and coloboma (MAC) are structural congenital eye malformations that cause a significant proportion of childhood visual impairments. Several disease genes have been identified but do not account for all MAC cases, suggesting that additional risk loci exist.
Jillian, Casey, Riki, Kawaguchi, Maria, Morrissey, Hui, Sun, Paul, McGettigan, Jens E, Nielsen, Judith, Conroy, Regina, Regan, Elaine, Kenny, Paul, Cormican, Derek W, Morris, Peter, Tormey, Muireann Ní, Chróinín, Breandan N, Kennedy, SallyAnn, Lynch, Andrew, Green, Sean, Ennis   +16 more
openaire   +7 more sources

Beyond a gatekeeper: the non-classical signaling role of STRA6 in driving endothelial senescence and atherosclerosis [PDF]

Frontiers in Immunology
Endothelial cell (EC) senescence is a fundamental driver of atherosclerosis. This review posits that the primary pathogenic role of Stimulated by Retinoic Acid 6 (STRA6) in the endothelium is not its canonical vitamin A transport but its non-classical ...
Yong Yuan, Jia Wang, Yunfang Zhang, Yan Yu, Weicheng Shi, Sulian Chen, Ye Kuang, Lei Feng   +7 more
doaj   +2 more sources

STRA6 is critical for cellular vitamin A uptake and homeostasis [PDF]

Human Molecular Genetics, 2014
Vitamin A must be adequately distributed within the body to maintain the functions of retinoids in the periphery and chromophore production in the eyes. Blood transport of the lipophilic vitamin is mediated by the retinol-binding protein, RBP4. Biochemical evidence suggests that cellular uptake of vitamin A from RBP4 is facilitated by a membrane ...
Amengual, Jaume, Zhang, Ning, Kemerer, Mary, Maeda, Tadao, Palczewski, Krzysztof, Von Lintig, Johannes   +5 more
openaire   +6 more sources

Single‐Cell and Bulk Transcriptomics Identify GNGT1‐High Malignant Epithelial Cells Associated With Immune Suppression in Esophageal Squamous Cell Carcinoma [PDF]

Chemical Biology &Drug Design, Volume 108, Issue 2, August 2026.
This study integrates single‐cell and bulk transcriptomes with machine learning to identify GNGT1 as an ESCC biomarker. Pan‐cancer, immune infiltration, pathway, and cell–cell communication analyses reveal TME associations. Exploratory treatment cohorts, in silico drug sensitivity, and molecular docking further support its therapeutic potential ...
Qian Yuan, Cheng Wang, Yintao Chang, Qiang Lyu, Yuxiang Jin, Lei Xue   +5 more
wiley   +2 more sources

Case-control analysis of SNPs in GLUT4, RBP4 and STRA6: association of SNPs in STRA6 with type 2 diabetes in a South Indian population.

PLoS ONE, 2010
BackgroundThe inverse relationship between GLUT4 and RBP4 expression is known to play a role in the pathogenesis of type 2 diabetes. Elevated levels of RBP4 were shown to cause insulin resistance in muscles and liver.
Anup Kumar Nair, Divya Sugunan, Harish Kumar, Gopalakrishnapillai Anilkumar   +3 more
doaj   +4 more sources

Structural and functional characterization of the retinol-binding protein receptor STRA6 [PDF]

, 2021
Vitamin A is an essential nutrient; it is not synthesized by mammals and therefore must be obtained through the diet. During times of fasting or dietary vitamin A insufficiency, retinol, the alcohol form of the vitamin is released from the liver, its main storage tissue, for circulation in complex with retinol-binding protein 4 (RBP) to provide an ...
Costabile, Brianna Kay
openaire   +3 more sources

ARNT2-driven transcriptional activation of STRA6 reprograms fatty acid metabolism to promote retroperitoneal liposarcoma progression [PDF]

Journal of Cancer Research and Clinical Oncology
Background Retroperitoneal liposarcoma (RLPS) is a mesenchymal-derived malignant tumor characterized by high aggressiveness and a propensity for local recurrence.
Junxiang Zhang, Hainan Guo, Bo Ban, Lin Yang, Jie Lian, Gan Li, Lindi Cai, Kai Deng, He Jiang, Xuqi Li, Shufeng Wang   +10 more
doaj   +2 more sources

STRA6: key to inflammatory pathways in COVID-19

, 2022
The COVID-19 pandemic, caused by SARS-CoV-2, has infected more than 260 million people worldwide, causing more than 5.2 million deaths. Unlike other viral infections, COVID-19 is characterized by widespread and severe systemic effects, immune dysregulation, pneumonia, ARDS, and multiple organ damage.
Aziz Rodan Sarohan
openaire   +2 more sources