Results 41 to 50 of about 2,199 (176)
STRA6-Catalyzed Vitamin A Influx, Efflux, and Exchange [PDF]
The Journal of Membrane Biology, 2012 Vitamin A has diverse biological functions and is essential for human survival. STRA6 is the high-affinity membrane receptor for plasma retinol binding protein (RBP), the principle and specific carrier of vitamin A (retinol) in the blood. It was previously shown that STRA6 couples to lecithin retinol acyltransferase (LRAT) and cellular retinol binding ...
Riki, Kawaguchi +4 more
openaire +2 more sources
Role of the STRA6 gene family in vertebrate development [PDF]
, 2013 Matthew-Wood syndrome is a rare human birth defect condition defined by the phenotypic constellation of clinical anophthalmia, diaphragmatic hernia, pulmonary hypoplasia and cardiac defects.
Wyatt, Niki Danielle
core +3 more sources
Journal of Lipid Research, 2016 Dyslipidemia has been proven to capably develop and aggravate chronic kidney disease. We also report that electronegative LDL (L5) is the most atherogenic LDL.
Chao-Hung Chen +10 more
doaj +1 more source
Frontiers in Oncology, 2020 Retinol plays a significant role in several physiological processes through their nuclear receptors, whose expression depends on retinol cytoplasmic concentration.
Saé Muñiz-Hernández +9 more
doaj +1 more source
Genetic dissection in mice reveals a dynamic crosstalk between the delivery pathways of vitamin A
Journal of Lipid Research, 2022 Vitamin A is distributed within the body to support chromophore synthesis in the eyes and retinoid signaling in most other tissues. Two pathways exist for the delivery of vitamin A: the extrinsic pathway transports dietary vitamin A in lipoproteins from ...
Jean Moon +2 more
doaj +1 more source
Correction: STRA6 polymorphisms are associated with EGFR mutations in locally-advanced and metastatic non-small cell lung cancer patients [PDF]
Frontiers in OncologySaé Muñiz-Hernández +9 more
doaj +2 more sources
Fenretinide: a novel treatment for endometrial cancer. [PDF]
PLoS ONE, 2014 Resistance to progestin treatment is a major hurdle in the treatment of advanced and reoccurring endometrial cancer. Fenretinide is a synthetic retinoid that has been evaluated in clinical trials as a cancer therapeutic and chemo-preventive agent ...
Navdha Mittal +8 more
doaj +1 more source
Natural Product Communications, 2023 Mychonastes sp. 247 is a newly isolated freshwater microalga. Mychonastes sp. 247 methanolic extract (ME) suppresses the growth of A549 human non-small-cell lung cancer (NSCLC) cells.
Soon Lee +7 more
doaj +1 more source
Expanding the phenotype of STRA6‐related disorder to include left ventricular non‐compaction
Molecular Genetics & Genomic Medicine, 2020 Background Syndromic microphthalmia‐9 (MCOPS9) is a rare autosomal recessive disorder caused by mutations in STRA6, an important regulator of vitamin A and retinoic acid metabolism.
Hairui Sun +5 more
doaj +1 more source
Cells, 2020 Dietary vitamin A/all-trans retinol/ROL plays a critical role in human vision. ROL circulates bound to the plasma retinol-binding protein (RBP4) as RBP4-ROL. In the eye, the STRA6 membrane receptor binds to circulatory RBP4 and internalizes ROL. STRA6 is,
Ashish K. Solanki +8 more
doaj +1 more source