Results 31 to 40 of about 2,199 (176)

Treg cells retain stable lineage commitment during pregnancy in mice after late gestation inflammatory challenge [PDF]

Immunology &Cell Biology, Volume 104, Issue 3, Page 276-311, March 2026.
In this study, we used Foxp3‐fatemapping mice to examine the cell lineage stability of Treg cells in pregnancy. Ex‐Foxp3 cells were identified in gestational tissues. However, Treg cells retained lineage stability with no increased ex‐Foxp3 generation, regardless of inflammatory challenges that induce preterm birth.
Kerrie L Foyle, Ella S Green, Jessie R Walker‐Rogers, Ha M Tran, David M Olson, Lachlan M Moldenhauer, Sarah A Robertson   +6 more
wiley   +2 more sources

STRA6 is Differentially Expressed by Human PBMC Subsets [PDF]

, 2019
Stimulated by retinoic acid 6 (STRA6) was the first protein to be identified in a novel category of proteins, cytokine signaling transporters, due to its ability to function as both a cell surface receptor and a membrane protein that binds to retinol ...
Barrett, Crisha Brooks
core   +7 more sources

Characterization of the Role of Stra6 in Tumor Suppression Mechanisms

, 2018
Stra6 is a protein that is upregulated in response to retinoids. Interestingly, we have found that Stra6 can induces p53 independently of DNA damage through ROS generation.
Marwah Suliman A. Maashi (7808300)
core   +7 more sources

Role of the STRA6 gene family in vertebrate development

, 2015
Matthew-Wood syndrome is a rare human birth defect condition defined by the phenotypic constellation of clinical anophthalmia, diaphragmatic hernia, pulmonary hypoplasia and cardiac defects. Matthew-Wood syndrome has a high mortality rate, with most patients dying due to respiratory insufficiency as a consequence of pulmonary hypoplasia, within the ...
Léopoldine Lequeux, Lequeux, Léopoldine, Jelena Martinovic-Bouriel, Sylvie Manouvrier-Hanu, Francesco Danilo Tiziano, Calvas, Patrick, Golzio, Christelle, Maragliano, Giovanna, Etchevers, Heather, C., Giovanna Maragliano, Adeline Vigouroux, Christelle Golzio, Francesca Piro, Piro, Francesca, Etchevers, Heather,, Patrick Calvas, Tania Attié-Bitach, Delezoide, Anne-Lise, Manouvrier-Hanu, Sylvie, Odent, Sylvie, Nicolas Chassaing, Sylvie Odent, Anne-Lise Delezoide, Masini, Lucia, Lucia Masini, Chassaing, Nicolas, Martinovic-Bouriel, Jelena, Tiziano, Francesco Danilo, Vigouroux, Adeline, Heather C. Etchevers, Attié-Bitach, Tania   +30 more
openaire   +3 more sources

Elevated RBP4 in Subclinical Ketosis Cows Inhibits Follicular Granulosa Cell Proliferation and Steroid Hormone Synthesis [PDF]

Animals
The mechanism by which subclinical ketosis (SCK) causes postpartum reproductive disorders in dairy cows remains unclear. In this study, cows within the day 14 to 21 postpartum period were categorized into the SCK group or the control group. Subsequently,
Chang Zhao, Ruru Xu, Weizhe Yan, Benzheng Jiang, Shibin Feng, Xichun Wang, Hongyan Ding   +6 more
doaj   +2 more sources

A master of all trades – linking retinoids to different signalling pathways through the multi-purpose receptor STRA6

Cell Death Discovery, 2021
Retinoids are a group of vitamin A-related chemicals that are essential to chordate mammals. They regulate a number of basic processes, including embryogenesis and vision.
Vinesh Dhokia, Salvador Macip
doaj   +1 more source

Downregulation of STRA6 in Adipocytes and Adipose Stromovascular Fraction in Obesity and Effects of Adipocyte-Specific STRA6 Knockdown In Vivo [PDF]

Molecular and Cellular Biology, 2014
To investigate the mechanisms by which elevated retinol-binding protein 4 (RBP4) causes insulin resistance, we studied the role of the high-affinity receptor for RBP4, STRA6 (stimulated by retinoic acid), in insulin resistance and obesity. In high-fat-diet-fed and ob/ob mice, STRA6 expression was decreased 70 to 95% in perigonadal adipocytes and both ...
Laura, Zemany, Bettina J, Kraus, Julie, Norseen, Tsugumichi, Saito, Odile D, Peroni, Randy L, Johnson, Barbara B, Kahn   +6 more
openaire   +2 more sources

Physiologically Relevant Free Ca2+ Ion Concentrations Regulate STRA6-Calmodulin Complex Formation via the BP2 Region of STRA6

Journal of Molecular Biology, 2021
The interaction of calmodulin (CaM) with the receptor for retinol uptake, STRA6, involves an α-helix termed BP2 that is located on the intracellular side of this homodimeric transporter (Chen et al., 2016 [1]). In the absence of Ca2+, NMR data showed that a peptide derived from BP2 bound to the C-terminal lobe (C-lobe) of Mg2+-bound CaM (MgCaM).
Brianna D, Young, Kristen M, Varney, Paul T, Wilder, Brianna K, Costabile, Edwin, Pozharski, Mary E, Cook, Raquel, Godoy-Ruiz, Oliver B, Clarke, Filippo, Mancia, David J, Weber   +9 more
openaire   +2 more sources

STRA6 Expression Serves as a Prognostic Biomarker of Gastric Cancer [PDF]

Cancer Genomics - Proteomics, 2020
Despite advances in our understanding on the pathogenesis of gastric cancer (GC), patients face a poor prognosis. To improve clinical outcomes, effective approaches to diagnosis and treatment employing new diagnostic biomarkers are required to achieve early detection and predict recurrence and prognosis.Transcriptome analysis was conducted using ...
Shunsuke, Nakamura, Mitsuro, Kanda, Dai, Shimizu, Kouichi, Sawaki, Chie, Tanaka, Norifumi, Hattori, Masamichi, Hayashi, Suguru, Yamada, Goro, Nakayama, Kenji, Omae, Masahiko, Koike, Yasuhiro, Kodera   +11 more
openaire   +2 more sources

Electronegative low‐density lipoprotein of patients with metabolic syndrome induces pathogenesis of aorta through disruption of the stimulated by retinoic acid 6 cascade

Journal of Diabetes Investigation, 2020
Aims/Introduction Electronegative low‐density lipoprotein (L5) is the most atherogenic fraction of low‐density lipoprotein and is elevated in people with metabolic syndrome (MetS), whereas the retinol‐binding protein 4 receptor (stimulated by retinoic ...
Chao‐Hung Chen, Liang‐Yin Ke, Hua‐Chen Chan, Chih‐Sheng Chu, An‐Sheng Lee, Kun‐Der Lin, Mei‐Yueh Lee, Pi‐Jung Hsiao, Chu‐Huang Chen, Shyi‐Jang Shin   +9 more
doaj   +1 more source