Results 21 to 30 of about 2,199 (176)

Role of stimulated by retinoic acid 6 in 46 children of coarctation of the aorta [PDF]

Heliyon
(1) ObjectiveCoarctation of the aorta (CoA) is a complex congenital heart disease. Research on differential genes in patients with CoA and other groups of aortas and investigating the pathogenesis of aorta coarctation is essential for prevention and ...
Xin Jin, Zhengxia Pan, Zhenjiang Zhao, Da Ouyang, Jinjie Qin, Jie Tian   +5 more
doaj   +2 more sources

Effect of Dietary Vitamin A, Breed, and Kidney Function on the Onset of Urinary Vitamin A Excretion and the Vitamin A Transport Complex in Growing Dogs [PDF]

Journal of Animal Physiology and Animal Nutrition, Volume 110, Issue 5, Page 813-819, September 2026.
ABSTRACT Vitamin A (retinol and retinyl esters) is present in substantial amounts in the urine of healthy adult dogs, but the mechanisms affecting its excretion are poorly understood. To assess whether the onset of urinary vitamin A excretion is dependent on dietary vitamin A intake, breed, and/or parameters of kidney function, 48 puppies from two ...
Jens Raila, Haydar Özpinar, Florian J. Schweigert   +2 more
wiley   +2 more sources

Retinoic Acid Signalling Regulates Zebrafish Tooth Germ Repair Following Injury [PDF]

Cell Proliferation, Volume 59, Issue 7, July 2026.
Retinoic acid signalling may regulate the repair processes in a tooth germ injury model using Tg(scpp5:Dendra2‐NTR) zebrafish and the nitroreductase (NTR)/metronidazole (MTZ) system. ABSTRACT Although the role of retinoic acid (RA) signalling in odontogenesis is well established, its involvement in the repair of injured tooth germs remains unclear.
Qiqi Liu, Zhenan Zhang, Weifeng Hao, Chunyan Zhou, Deqin Yang   +4 more
wiley   +2 more sources

Recent Polygenic Adaptation in Heavily Fished Malawi Cichlids [PDF]

Molecular Ecology, Volume 35, Issue 12, June 2026.
ABSTRACT Intense fishing pressure can drive rapid evolution in wild populations, yet the underlying genomic mechanisms often remain elusive. Here, we investigate the genomic consequences of five decades of intense harvesting on the cichlid fish Copadichromis mloto in Lake Malombe, Malawi.
Alexander Hooft van Huysduynen, Francisco Campuzano Jiménez, Julia Camacho Garcia, Gudrun De Boeck, Bosco Rusuwa, Hannes Svardal   +5 more
wiley   +2 more sources

Senescent endothelial cells: key commanders of the cellular communication network within atherosclerotic plaques [PDF]

Frontiers in Immunology
Endothelial cell senescence, once considered a passive manifestation of vascular aging, is now recognized as an active driver of atherosclerosis. Senescent endothelial cells (sECs) exhibit distinct morphological and molecular hallmarks, including ...
Fujia Xie, Cheng Xi, Guoqing Bao, Bin Yang, Xiaoyu Zheng, Bowen Fu, Zhibin Zheng   +6 more
doaj   +2 more sources

Regional heterogeneity of the blood-brain barrier [PDF]

Nature Communications
The blood-brain barrier (BBB), formed by specialized endothelial cells (ECs), regulates the extracellular composition of the central nervous system (CNS).
Marie Blanchette, Kaja Bajc, Benjamin D. Gastfriend, Caterina P. Profaci, Nadine Ruderisch, Cayce E. Dorrier, Guo Zhong, Raquel Cuevas-Diaz Duran, Sean S. Harvey, Iris H. Garcia-Pak, Lucija Pintarić, Manon Leclerc, Louise Reveret, Vincent Émond, Annette Wang, Deepti Pant, Linus T. Tsai, Frédéric Calon, Nina Isoherranen, Sean P. Palecek, Eric V. Shusta, Jiaqian Wu, Richard Daneman   +22 more
doaj   +2 more sources

The Effects of STRA6 Regulation of the Circadian Rhythm on Choroidal Neovascularization [PDF]

Investigative Ophthalmology & Visual Science
This study aims to investigate the relationship among STRA6, circadian rhythm, and choroidal neovascularization (CNV) formation, as well as the regulatory mechanism of STRA6 in CNV under circadian rhythm disturbances.C57BL/6J male mice (aged 6 weeks) were randomly divided into control and jet lag groups (using a time shift method every 4 days to ...
Yang, Ying, Zhang, Shenglai, Su, Shu, Yang, Xiaowei, Chen, Jia, Sang, Aimin   +5 more
openaire   +3 more sources

Maternal obesity remodels nutrient transport transcriptional programs in early mouse embryonic and extraembryonic cell lineages [PDF]

Molecular Metabolism
Background: Maternal obesity increases the risk of congenital anomalies and later-life metabolic disease in offspring. Still, underlying mechanisms remain unclear, particularly in extraembryonic lineages at the maternal–fetal interface, which remain ...
Amalia Caballero, Lijun Chi, Paul Delgado-Olguín   +2 more
doaj   +2 more sources

Dialogue Between the Clock Gene Bmal1 and Retinopathy: What Is the Exact Relationship? [PDF]

CNS Neuroscience &Therapeutics, Volume 31, Issue 11, November 2025.
Circadian rhythm is offering novel insights into the pathogenesis of retinopathy. Bmal1, a key transcriptional regulator of the circadian clock, serves as a critical pathologic cofactor in retinal degeneration. Deficiency in Bmal1 contributes to a broad spectrum of retinal pathological alterations, and modulating the clock gene Bmal1 could potentially ...
Yongheng Cui, Haoyan Li, Wenhui Fan, Hao Wu, Jiale Wang, Chengkang Qu, Ning Pu, Ye Tao   +7 more
wiley   +2 more sources

Vitamin A retinoic acid contributes to muscle stem cell and mitochondrial function loss in old age [PDF]

JCI Insight
Adult stem cells decline in number and function in old age, and identifying factors that can delay or revert age-associated adult stem cell dysfunction are vital for maintaining a healthy lifespan.
Paula M. Fraczek, Pamela Duran, Benjamin A. Yang, Valeria Ferre, Leanne Alawieh, Jesus A. Castor-Macias, Vivian T. Wong, Steve D. Guzman, Celeste Piotto, Klimentini Itsani, Jacqueline A. Larouche, Carlos A. Aguilar   +11 more
doaj   +2 more sources