Results 51 to 60 of about 21,878 (196)

Structural and biochemical basis for retinol‐binding protein 4 antagonism by tinlarebant

British Journal of Pharmacology, EarlyView.
Background and Purpose Retinol‐binding protein 4 (RBP4) is a member of the lipocalin superfamily that is connected to disease states such as insulin resistance, fatty liver disease and ocular disorders including Stargardt disease. Several retinoid and non‐retinoid antagonists of this protein have been developed for potential clinical use, but none have
Marco Bassetto, Philip D. Kiser
wiley   +1 more source

IL-1β decreases RBP4 production.

, 2013
SGBS adipocytes were treated with increasing doses of IL-1β (0.05, 0.5, 5, 50 ng/ml) or the corresponding vehicle control. (A) RBP4 mRNA expression was measured by quantitative PCR.
Pamela Fischer-Posovszky (219549), Primoz Kotnik (382835), Michaela Keuper (382836), Martin Wabitsch (132974)   +3 more
core   +1 more source

Chronic silencing of subsets of cortical layer 5 pyramidal neurons has a long‐term influence on the laminar distribution of parvalbumin interneurons and the perineuronal nets

Journal of Anatomy, Volume 246, Issue 4, Page 479-504, April 2025.
Chronic silencing of subsets of layer 5 projection neurons has distinct effects on the laminar distribution of PV interneurons and the perineuronal nets in the adult primary motor and somatosensory cortex. Abstract Neural networks are established throughout cortical development, which require the right ratios of glutamatergic and GABAergic neurons ...
Florina P. Szabó, Veronika Sigutova, Anna M. Schneider, Anna Hoerder‐Suabedissen, Zoltán Molnár   +4 more
wiley   +1 more source

Role of retinol binding protein 4, visfatin, omentin-1 and vaspin in gout patients with various obesity phenotypes

Российский кардиологический журнал
Aim. To study the serum level of retinol-binding protein 4 (RBP4), visfatin, omentin-1 and vaspin in gout patients with different obesity phenotypes, as well as to assess the dynamics of studied parameters against the background of weight loss using an ...
N. N. Pavlova, E. V. Volgina, T. A. Medvedeva, N. Yu. Mishko   +3 more
doaj   +1 more source

Retinol‐Binding Protein 4 Promotes Cardiac Injury After Myocardial Infarction Via Inducing Cardiomyocyte Pyroptosis Through an Interaction With NLRP3

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background Acute myocardial infarction (AMI) is one of the leading causes of cardiovascular morbidity and mortality worldwide. Pyroptosis is a form of inflammatory cell death that plays a major role in the development and progression of cardiac injury in
Kang‐Zhen Zhang, Xi‐Yu Shen, Man Wang, Li Wang, Hui‐Xian Sun, Xiu‐Zhen Li, Jing‐Jing Huang, Xiao‐Qing Li, Cheng Wu, Can Zhao, Jia‐Li Liu, Xiang Lu, Wei Gao   +12 more
doaj   +1 more source

Vitamins and Chronic Wounds: How Altered Pharmacokinetics and Comorbidities Contribute to Vitamin Deficiencies

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 4, October 2026.
ABSTRACT Wound healing is complex and requires adequate amounts of macro‐ and micronutrients. When wound healing is delayed, a wound is considered chronic. Increasing evidence shows that vitamin deficiencies are prevalent in patients with chronic wounds, yet intervention studies with vitamin supplementation yielded inconsistent effects.
Michiel G. J. Balvers, Teuntje L. de Smit, Anne I. Slotegraaf, Remy H. H. Bemelmans, Joé L. P. Kolkert, Tim J. Schuijt, Renger F. Witkamp   +6 more
wiley   +1 more source

Macrophage-secreted factors decrease RBP4 production.

, 2013
SGBS adipocytes (A, B, C) were treated with increasing concentrations of MacCM (5, 10, 20, 50%) or the corresponding vehicle control. (A) Representative pictures of cells treated for 48 hours with 10% of MacCM.
Pamela Fischer-Posovszky (219549), Primoz Kotnik (382835), Michaela Keuper (382836), Martin Wabitsch (132974)   +3 more
core   +1 more source

DataSheet1_Mapping of the extracellular RBP4 ligand binding domain on the RBPR2 receptor for Vitamin A transport.PDF

, 2023
The distribution of dietary vitamin A/all-trans retinol/ROL throughout the body is critical for maintaining retinoid function in peripheral tissues and for retinoid delivery to the eye in the support of visual function.
Matthias Leung (14661332), Rakesh Radhakrishnan (4807785), Ashish K. Solanki (14661335), Glenn P. Lobo (3177678)   +3 more
core   +1 more source

mRNA Therapeutics for Skin Rejuvenation: From Aging Atlases to Clinical Translation

Experimental Dermatology, Volume 35, Issue 10, October 2026.
ABSTRACT Skin aging is a multifactorial process characterized by the progressive decline of tissue structure, function and regenerative capacity. Although numerous interventions have been developed to improve the clinical manifestations of aging, most primarily alleviate downstream consequences rather than directly targeting the molecular mechanisms ...
Fabiana Boncimino, Stefano Sol, Kristina Todorova, Anna Mandinova   +3 more
wiley   +1 more source

The Camp-HMGA1-RBP4 System [PDF]

BMC Biology, 2009
Abstract Background We previously showed that mice lacking the high mobility group A1 gene (Hmga1-knockout mice) developed a type 2-like diabetic phenotype, in which cell-surface insulin receptors were dramatically reduced (below 10% of those in the controls) in the major targets of insulin action, and glucose ...
Chiefari E., Paonessa F., Iiritano S, Le Pera I., PALMIERI, DARIO, Brunetti G., Lupo A., Colantuoni V., Foti D., Gulletta E., De Sarro G., FUSCO, ALFREDO, Brunetti A.   +12 more
openaire   +6 more sources