Results 61 to 70 of about 20,257 (224)

Comparative pharmacokinetics and pharmacodynamics of the advanced Retinol-Binding Protein 4 antagonist in dog and cynomolgus monkey.

PLoS ONE, 2020
Accumulation of lipofuscin bisretinoids in the retina contributes to pathogenesis of macular degeneration. Retinol-Binding Protein 4 (RBP4) antagonists reduce serum retinol concentrations thus partially reducing retinol delivery to the retina which ...
Boglarka Racz, Andras Varadi, Paul G Pearson, Konstantin Petrukhin   +3 more
doaj   +1 more source

A Functional Binding Domain in the Rbpr2 Receptor Is Required for Vitamin A Transport, Ocular Retinoid Homeostasis, and Photoreceptor Cell Survival in Zebrafish

Cells, 2020
Dietary vitamin A/all-trans retinol/ROL plays a critical role in human vision. ROL circulates bound to the plasma retinol-binding protein (RBP4) as RBP4-ROL. In the eye, the STRA6 membrane receptor binds to circulatory RBP4 and internalizes ROL. STRA6 is,
Ashish K. Solanki, Altaf A. Kondkar, Joseph Fogerty, Yanhui Su, Seok-Hyung Kim, Joshua H. Lipschutz, Deepak Nihalani, Brian D. Perkins, Glenn P. Lobo   +8 more
doaj   +1 more source

Systematic Quantification of Neurotrophic Adipokines RBP4, PEDF, and Clusterin in Human Cerebrospinal Fluid and Serum.

Journal of Clinical Endocrinology and Metabolism, 2021
CONTEXT Data on the presence/quantification of the neurotrophic adipokines retinol-binding protein-4 (RBP4), clusterin, and pigment epithelium-derived factor (PEDF) in human cerebrospinal fluid (CSF) are scarce and migration of these adipokines across of
Alexandra Höpfinger, M. Berghoff, T. Karrasch, A. Schmid, A. Schäffler   +4 more
semanticscholar   +1 more source

Decreased Retinol Binding Protein 4 Concentrations are Associated With Cholesterol Gallstone Disease

Journal of the Formosan Medical Association, 2010
Circulating retinol binding protein 4 (RBP4) is associated with a variety of obesity-related diseases. This study investigated whether there were aberrant concentrations of RBP4 in cholesterol gallstone disease.
Shen-Nien Wang, Yao-Tsung Yeh, Sen-Teh Wang, Yi-Ling Chen, Shih-Chang Chuang, Chen-Guo Ker, King-Teh Lee   +6 more
doaj   +1 more source

Association of RBP4 Genotype with Phenotypic Reproductive Traits of Sows [PDF]

Genetics Research International, 2016
PCR-RFLP was applied to a commercial crossbred pig population in order to investigate the association between polymorphism (SNP) of Retinol-binding protein 4 (RBP4) gene and reproductive performance. 400 sows were genotyped and 2000 records of reproductive traits were used in order to retrieve information about the allele frequencies and the ...
Marantidis, A., Laliotis, G. P., Avdi, M.   +2 more
openaire   +2 more sources

The Relationship between Retinol-Binding Protein 4 and Markers of Inflammation and Thrombogenesis in Children with Kawasaki Disease

Mediators of Inflammation, 2021
Background. Kawasaki disease (KD) is a self-limited vasculitis with unknown etiologies, and coronary artery lesions (CALs) are the most common and serious complications.
Maoling Yang, Haobo Weng, Qiongfei Pei, Fengchuan Jing, Qijian Yi   +4 more
doaj   +1 more source

An RBP4 promoter polymorphism increases risk of type 2 diabetes [PDF]

Diabetologia, 2008
Retinol-binding protein 4 (RBP4), originally known for retinol transport, was recently identified as an adipokine affecting insulin resistance. The RBP4 -803GA promoter polymorphism influences binding of hepatic nuclear factor 1alpha and is associated with type 2 diabetes in case-control studies.
van der Hoek, M, Dehghan, Abbas, Zillikens, M.C., Hofman, Bert, Witteman, JCM, Sijbrands, E.J.G.   +5 more
openaire   +2 more sources

Adipokines as New Biomarkers of Immune Recovery: Apelin Receptor, RBP4 and ZAG Are Related to CD4+ T-Cell Reconstitution in PLHIV on Suppressive Antiretroviral Therapy

International Journal of Molecular Sciences, 2022
A significant proportion of people living with HIV (PLHIV) who successfully achieve virological suppression fail to recover CD4+ T-cell counts. Since adipose tissue has been discovered as a key immune organ, this study aimed to assess the role of ...
Elena Yeregui, Jenifer Masip, C. Viladés, P. Domingo, Y. Pacheco, J. Blanco, J. Mallolas, V. Alba, M. Vargas, G. García-Pardo, E. Negredo, M. Olona, Judit Vidal-González, M. Peraire, Anna Martí, Laia Reverté, F. Gómez-Bertomeu, M. Leal, F. Vidal, J. Peraire, A. Rull   +20 more
semanticscholar   +1 more source

Childhood retinol-binding protein 4 (RBP4) levels predicting the 10-year risk of insulin resistance and metabolic syndrome: the BCAMS study

Cardiovascular Diabetology, 2018
Background Elevated retinol-binding protein 4 (RBP4) levels may contribute to the development of metabolic abnormalities, but prospective studies evaluating the association between childhood RBP4 levels and metabolic syndrome (MS) in adulthood are ...
Ge Li, Issy C. Esangbedo, Lu Xu, Junling Fu, Lujiao Li, Dan Feng, Lanwen Han, Xinhua Xiao, Mingyao Li, Jie Mi, Ming Li, Shan Gao, Steven M. Willi   +12 more
doaj   +1 more source

Plasma retinol-binding protein 4 in the first and second trimester and risk of gestational diabetes mellitus in Chinese women: a nested case-control study

Nutrition & Metabolism, 2020
Background To assess the association between plasma retinol-binding protein 4 (RBP4) levels both in the first trimester and second trimester and risk of gestational diabetes mellitus (GDM).
Chuyao Jin, Lizi Lin, Na Han, Zhiling Zhao, Zheng Liu, Shusheng Luo, Xiangrong Xu, Jue Liu, Haijun Wang   +8 more
doaj   +1 more source