Results 11 to 20 of about 202,542 (217)
Cells, 2021 In human cells, each rDNA unit consists of the ~13 kb long ribosomal part and ~30 kb long intergenic spacer (IGS). The ribosomal part, transcribed by RNA polymerase I (pol I), includes genes coding for 18S, 5.8S, and 28S RNAs of the ribosomal particles, as well as their four transcribed spacers.
Evgeny Smirnov +2 more
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RNA polymerase II-mediated rDNA transcription mediates rDNA copy number expansion in Drosophila.
PLoS GeneticsRibosomal DNA (rDNA), which encodes ribosomal RNA, is an essential but unstable genomic element due to its tandemly repeated nature. rDNA's repetitive nature causes spontaneous intrachromatid recombination, leading to copy number (CN) reduction, which ...
George J Watase, Yukiko M Yamashita
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Variability of Human rDNA [PDF]
Cells, 2021 In human cells, ribosomal DNA (rDNA) is arranged in ten clusters of multiple tandem repeats. Each repeat is usually described as consisting of two parts: the 13 kb long ribosomal part, containing three genes coding for 18S, 5.8S and 28S RNAs of the ribosomal particles, and the 30 kb long intergenic spacer (IGS).
Evgeny Smirnov +4 more
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Calorie restriction reduces rDNA recombination independently of rDNA silencing [PDF]
Aging Cell, 2009 SummaryCalorie restriction (CR) extends lifespan in yeast, worms, flies and mammals, suggesting that it acts via a conserved mechanism. In yeast, activation of the NAD‐dependent histone deacetylase, Sir2, by CR is thought to increase silencing at the ribosomal DNA, thereby reducing the recombination‐induced generation of extrachromosomal rDNA circles ...
Riesen, Michèle, Morgan, Alan
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Autophagy deficiency activates rDNA transcription
Autophagy, 2021 Macroautophagy/autophagy, a highly conserved lysosome-dependent degradation pathway, has been intensively studied in regulating cell metabolism by degradation of intracellular components. In this study, we link autophagy to RNA metabolism by uncovering a regulatory role of autophagy in ribosomal RNA (rRNA) synthesis.
Yinfeng, Xu +9 more
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Allelic inactivation of rDNA loci [PDF]
Genes & Development, 2009 Human cells contain several hundred ribosomal genes (rDNA) that are clustered into nucleolar organizer regions (NORs) on the short arms of five different acrocentric chromosomes. Only ∼50% of the gene copies are actually expressed in somatic cells. Here, we used a new cytological technique to demonstrate that rDNA is regulated allelically in a regional
Sharon, Schlesinger +3 more
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Increased sampling reveals novel lineages of Entamoeba: consequences of genetic diversity and host specificity for taxonomy and molecular detection. [PDF]
, 2011 To expand the representation for phylogenetic analysis, ten additional complete Entamoeba small-subunit rRNA gene sequences were obtained from humans, non-human primates, cattle and a tortoise. For some novel sequences no corresponding morphological data
Alfellani, Mohammed +7 more
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Spatial distribution, host specificity and genetic diversity of Onchobothrium antarcticum in the Southern Ocean [PDF]
Polish Polar Research, 2021 In this work we summarize the current knowledge on the spatial distribution, host specificity and genetic diversity of Onchobothrium antarcticum, an endemic Antarctic cestode.
Ilya I. Gordeev +2 more
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Next generation sequencing analysis reveals a relationship between rDNA unit diversity and locus number in Nicotiana diploids [PDF]
, 2012 © 2012 Matyášek et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and ...
Fulnecek, J +7 more
core +5 more sources
Genomic organization of rat rDNA [PDF]
Nucleic Acids Research, 1983 A detailed restriction map was determined for a 10.9 KB region that contains the initiation site for 45S pre-rRNA and the first 1.7 KB of the 18S rRNA coding region. When the restriction pattern of the cloned rDNA was compared with that of total rat DNA, the rDNA regions of both Sprague-Dawley and BD-9 rats were identical to each other and to that of ...
D M, Chikaraishi +3 more
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