Results 111 to 120 of about 37,264 (315)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Thermal optimization in time-dependent magnetohydrodynamic bioconvective flow of Casson hybrid nanofluid through a squeezing channel: Entropy analysis

Next Materials
Efficient thermal management in hybrid nanofluid flows characterized by non-Newtonian behavior and bioconvection has gained significance due to its relevance in advanced thermal engineering systems, biomedical technologies, and energy transport ...
Seetalsmita Samal, Surender Ontela
doaj   +1 more source

The Cash Flow Model with Float: A New Approach to Deal with Valuation and Agency Problems. [PDF]

In this paper we introduce a cash flow model with float to manage core issues in Corporate Finance. The float actually removes current hindrances pervading the standard cash flow model.
Rodolfo Apreda
core  

Cumulative compressibility effects on slow reactive dynamics in turbulent flows

, 2013
Reactions in turbulent flows, chemical reactions or combustion, are common. Typically reaction time scales are much shorter than turbulence timescales. In biological applications, as it is the case for bacterial and plankton populations living under the ...
TOSCHI, FRANCESCO, Toschi, F., Perlekar, P, Toschi, F.; id_orcid, Benzi, R, Toschi, F, Perlekar, P., Nelson, D.R., Nelson, D, Benzi, R., BENZI, ROBERTO   +10 more
core   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Bubble dynamics in polymeric foams [PDF]

, 2004
The effects of fluid viscoelasticity on the expansion of gas bubbles in polymer foams for both non-reactive and reactive polymers are investigated. Polymer foams are used extensively in consumer products, from car parts to upholstery.
Everitt, Sally Louise
core  

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Transient magnetohydrodynamic flow over a rotating vertical porous surface incorporating thermal radiation, hall and ion-slip effects: Using finite element method

Results in Chemistry
The current study investigates the combined influence of thermal radiation, rotation, Hall and ion-slip effects, chemical reactions, and viscous dissipation on unsteady convective heat and mass transfer past a finite, non-reflective vertical plate.
Kamala Pratapa, Shankar Gollapalli, Siva Reddy Sheri, Muhammad Awais, Hakim AL Garalleh, Afnan Al Agha   +5 more
doaj   +1 more source

"Concept and Relevance of Income" [PDF]

Recently, many people criticize the traditionally accepted principles of realization, matching, and allocation. In addition, the reporting performance project in the International Accounting Standards Board (IASB) is willing to substitute the extant ...
Takashi Obinata
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source