Results 251 to 260 of about 124,194 (317)
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Experimental and Molecular Therapeutics, 2021
Mutations in the TP53 gene are the most frequent somatic alterations in human cancer; approximately 50% of all human cancers possess mutations in TP53. Missense mutations in TP53 which result in a non-functional protein are the most frequently identified,
M. Dumble +15 more
semanticscholar +1 more source
Mutations in the TP53 gene are the most frequent somatic alterations in human cancer; approximately 50% of all human cancers possess mutations in TP53. Missense mutations in TP53 which result in a non-functional protein are the most frequently identified,
M. Dumble +15 more
semanticscholar +1 more source
Mutant p53 reactivator SLMP53-2 hinders ultraviolet B radiation-induced skin carcinogenesis.
Pharmacological Research, 2021The growing incidence of skin cancer (SC) has prompted the search for additional preventive strategies to counteract this global health concern. Mutant p53 (mutp53), particularly with ultraviolet radiation (UVR) signature, has emerged as a promising ...
Joana B Loureiro +11 more
semanticscholar +1 more source
Synthesis and Molecular Properties of Nerve Agent Reactivator HLö-7 Dimethanesulfonate
ACS Medicinal Chemistry Letters, 2019 The threat of a deliberate release of chemical nerve agents has underscored the need to continually improve field effective treatments for these types of poisonings. The oxime containing HLö-7 is a potential second-generation therapeutic reactivator.
Scott D Pegan
exaly +2 more sources
Journal of Enzyme Inhibition and Medicinal Chemistry, 2010 Kamil Kuca, Kamil Musilek, Daniel Jun
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Dalton Transactions, 2022
The reactivity of the tungsten diphenylarsinocarbyne [W(CAsPh2)(CO)2(Tp*)] (1; Tp* = hydrotris(dimethylpyrazolyl)borato) is described leading to the first examples of bridging arsino- and arsoniocarbyne complexes.
Benjamin J. Frogley, Anthony F. Hill
openaire +2 more sources
The reactivity of the tungsten diphenylarsinocarbyne [W(CAsPh2)(CO)2(Tp*)] (1; Tp* = hydrotris(dimethylpyrazolyl)borato) is described leading to the first examples of bridging arsino- and arsoniocarbyne complexes.
Benjamin J. Frogley, Anthony F. Hill
openaire +2 more sources
The Journal of Physical Chemistry A, 2021
The chemical reactivity of a molecule as a whole or of an atom in a molecule varies during a chemical reaction. A variation of global and local reactivity descriptors in the course of a physicochemical process was studied within a quantum fluid density functional theory framework.
Utpal Sarkar, Pratim Kumar Chattaraj
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The chemical reactivity of a molecule as a whole or of an atom in a molecule varies during a chemical reaction. A variation of global and local reactivity descriptors in the course of a physicochemical process was studied within a quantum fluid density functional theory framework.
Utpal Sarkar, Pratim Kumar Chattaraj
openaire +2 more sources
Journal of Biological Chemistry, 2019 Exposure to organophosphorus compounds (OPs) may be fatal if untreated, and a clear and present danger posed by nerve agent OPs has become palpable in recent years.
Oksana Gerlits +2 more
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Acetylcholinesterase liquid crystal biosensor for identification of AChE inhibitors by a reactivator
Science China Chemistry, 2014Fubing Xiao, Zhaoyang Wu
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Current Opinion in Rheumatology, 1996
The complex interactions between the triggering microbe and the defense mechanisms of the host in reactive arthritis have been studied in several laboratories around the world, and interesting observations have been made. Research has also focused on the mediators in the inflammatory process in joints, and these results are helping to slowly build a ...
A, Toivanen, P, Toivanen
openaire +7 more sources
The complex interactions between the triggering microbe and the defense mechanisms of the host in reactive arthritis have been studied in several laboratories around the world, and interesting observations have been made. Research has also focused on the mediators in the inflammatory process in joints, and these results are helping to slowly build a ...
A, Toivanen, P, Toivanen
openaire +7 more sources