Results 71 to 80 of about 5,854,385 (285)

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

Fluorescence response of H₂DCFDA to various reactive oxygen and reactive nitrogen species [28].

, 2013
Fluorescence response of H2DCFDA to various reactive oxygen and reactive nitrogen species [28].
Morten F. Tonnesen (361023), Schott Heller (361024), Flemming Pociot (42186), Allan E. Karlsen (361027), Josefine Friberg (361022), Thóra B. Bödvarsdottir (361026)   +5 more
core   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Scavenging of reactive oxygen and nitrogen species with nanomaterials [PDF]

Nano Research, 2018
Reactive oxygen and nitrogen species (RONS) are essential for normal physiological processes and play important roles in cell signaling, immunity, and tissue homeostasis. However, excess radical species are implicated in the development and augmented pathogenesis of various diseases.
Carolina A, Ferreira, Dalong, Ni, Zachary T, Rosenkrans, Weibo, Cai   +3 more
openaire   +2 more sources

Characterization of the key membrane protein cytochrome Cyc2 from Ghiorsea bivora

FEBS Open Bio, EarlyView.
This study reports the first detailed biochemical analysis of Cyc2TAG1_1, a cytochrome protein involved in microbial iron oxidation. We produced and purified this enzyme in E. coli, then measured its iron‐oxidizing efficiency, and characterized its electrical and structural properties.
Josiane Azizi, Alain Dolla, Frauke Baymann, Celine Rommevaux, Latifa Elantak, Helene Gaussier, Matthieu Nouailler   +6 more
wiley   +1 more source

Nitrated Nucleotides: New Players in Signaling Pathways of Reactive Nitrogen and Oxygen Species in Plants

Frontiers in Plant Science, 2020
Nitration of diverse biomolecules, including proteins, lipids and nucleic acid, by reactive nitrogen species represents one of the key mechanisms mediating nitric oxide (NO) biological activity across all types of organisms.
Marek Petřivalský, Lenka Luhová
doaj   +1 more source

Roles of reactive oxygen and nitrogen species in pain [PDF]

Free Radical Biology and Medicine, 2011
Peroxynitrite (PN; ONOO⁻) and its reactive oxygen precursor superoxide (SO; O₂•⁻) are critically important in the development of pain of several etiologies including pain associated with chronic use of opiates such as morphine (also known as opiate-induced hyperalgesia and antinociceptive tolerance).
Daniela, Salvemini, Joshua W, Little, Timothy, Doyle, William L, Neumann   +3 more
openaire   +2 more sources

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Signalling pathways involved in TNFα-induced cytoprotection : role of reactive oxygen species [PDF]

, 2005
Includes bibliographical references (leaves 73-89).Tumour necrosis factor alpha (TNFa) is a pleiotropic cytokine which has both beneficial and deleterious effects.
Lacerda, Lydia
core   +1 more source

Dissolved black nitrogen: an overlooked active nano-catalyst in the abiotic transformation of chlorophenols by sulfides in the subsurface water

Biochar
The incomplete combustion of biomass and fossil fuels results in the formation of not only black carbon (BC) but also black nitrogen (BN), the dissolved fractions of which (i.e., DBC and DBN) are important components of dissolved organic matter pool ...
Yikang Zhang, Meiyan Wang, Yiwen Wang, Fei Wang, Yan Gong, Kaiyue Yin, Fei Lian, Baoshan Xing   +7 more
doaj   +1 more source