Results 111 to 120 of about 1,596,363 (414)
Heliyon, 2020 Legionella grows intracellularly in free-living amoeba as well as in mammalian macrophages. Until now, the overall gene expression pattern of intracellular Legionella in Acanthamoeba was not fully explained. Intracellular bacteria are capable of not only
Fu-Shi Quan +4 more
doaj
Oxygen depletion in FLASH ultra-high-dose-rate radiotherapy: A molecular dynamics simulation [PDF]
, 2020 We present a first-principles molecular dynamics (MD) simulation and expound upon a mechanism of oxygen depletion hypothesis to explain the mitigation of normal tissue injury observed in ultra-high-dose-rate (UHDR) FLASH radiotherapy. We simulated damage to a segment of DNA (also representing other bio-molecules such as RNA and proteins) in a ...
arxiv +1 more source
Reactive oxygen species and cellular oxygen sensing [PDF]
Free Radical Biology and Medicine, 2007 Many organisms activate adaptive transcriptional programs to help them cope with decreased oxygen (O(2)) levels, or hypoxia, in their environment. These responses are triggered by various O(2) sensing systems in bacteria, yeast and metazoans. In metazoans, the hypoxia inducible factors (HIFs) mediate the adaptive transcriptional response to hypoxia by ...
M. Celeste Simon +2 more
openaire +3 more sources
Molecular Oncology, EarlyView.Pancreatic ductal adenocarcinoma (PDAC) is a disease with very poor prognosis due to therapeutic limitations. We investigated the antitumor effects of cystatin A (CSTA) in PDAC murine models. We are first to confirm that CSTA enhances T helper type 1‐mediated antitumor effects through promotion of dendritic cells and M1 macrophage activity. CSTA can be
Alessandro Nasti +8 more
wiley +1 more source
Frontiers in Physiology, 2021 Mitochondria are known to generate approximately 90% of cellular reactive oxygen species (ROS). The imbalance between mitochondrial reactive oxygen species (mtROS) production and removal due to overproduction of ROS and/or decreased antioxidants defense ...
Hasna Tirichen +5 more
semanticscholar +1 more source
A quantum protective mechanism in photosynthesis [PDF]
Scientific Reports 5, Article number: 8720 (2015), 2016 Since the emergence of oxygenic photosynthesis, living systems have developed protective mechanisms against reactive oxygen species. During charge separation in photosynthetic reaction centres, triplet states can react with molecular oxygen generating destructive singlet oxygen.
arxiv +1 more source
Molecular Oncology, EarlyView.The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita +1 more
wiley +1 more source
Influenza A hemagglutinin virus-like particles confer protection against influenza B virus infection
Emerging Microbes and InfectionsInfluenza A hemagglutinin (HA), neuraminidase, and/or M2e-containing virus-like particles (VLPs) induce immune responses that contribute to protection against multiple influenza A virus subtypes.
Jie Mao +7 more
doaj +1 more source
Reactive oxygen species in plant development [PDF]
, 2018 Reactive oxygen species (ROS) are produced by metabolic pathways in almost all cells. As signaling components, ROS are best known for their roles in abiotic and biotic stress-related events.
M'Hamdi, Amna, Van Breusegem, Frank
core +2 more sources
Reactive Oxygen Species: Drivers of Physiological and Pathological Processes
Journal of Inflammation Research, 2020 Since the Great Oxidation Event, about 2.4 billion years ago, the Earth is immersed in an oxidizing atmosphere. Thus, it has been proposed that excess oxygen, originally a waste product of photosynthetic cyanobacteria, induced oxidative stress and the ...
J. Checa, J. Aran
semanticscholar +1 more source