Results 91 to 100 of about 712,690 (299)
FEBS Open Bio, EarlyView.Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid +3 more
wiley +1 more source
The Role of Oxidative Stress in the Aging Process
The Scientific World Journal, 2010 The aging of organisms is characterized by a gradual functional decline of all organ systems. An appropriate theory must explain four main characteristics of aging: it is progressive, endogenous, irreversible, and deleterious for the individual.
Barbara F. Oliveira +2 more
doaj +1 more source
Reactive Oxygen Species (ROS)-Responsive Nanomedicine for Solving Ischemia-Reperfusion Injury
Frontiers in Chemistry, 2020 Ischemia-reperfusion injury (IRI) is a severe condition for most organs, which could occur in various tissues including brain, heart, liver, and kidney, etc.
Weiyu Chen, Weiyu Chen, Deling Li
doaj +1 more source
Redox signaling, Nox5 and vascular remodeling in hypertension [PDF]
, 2015 Purpose of review: Extensive data indicate a role for reactive oxygen species (ROS) and redox signaling in vascular damage in hypertension. However, molecular mechanisms underlying these processes remain unclear, but oxidative post-translational ...
De Lucca Camargo, Livia +5 more
core +1 more source
FEBS Open Bio, EarlyView.We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies +3 more
wiley +1 more source
AntioxidantsReactive oxygen species (ROS) are chemically reactive oxygen-containing compounds generated by various factors in the body. Antioxidants mitigate the damaging effects of ROS by playing a critical role in regulating redox balance and signaling.
Dilara Kilicarslan You +6 more
doaj +1 more source
Targeting NOX enzymes in the central nervous system: therapeutic opportunities [PDF]
, 2018 Among the pathogenic mechanisms underlying central nervous system (CNS) diseases, oxidative stress is almost invariably described. For this reason, numerous attempts have been made to decrease reactive oxygen species (ROS) with the administration of ...
Jaquet, Vincent +2 more
core
Superoxide Radical Dismutation as New Therapeutic Strategy in Parkinson’s Disease [PDF]
, 2017 open4siAging is the biggest risk factor for developing many neurodegenerative disorders, including idiopathic Parkinson's disease (PD). PD is still an incurable disorder and the available medications are mainly directed to the treatment of symptoms in ...
core +1 more source
The role of lipid metabolism in neuronal senescence
FEBS Open Bio, EarlyView.Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari +2 more
wiley +1 more source
Hypobranching Induced by Both Environmental Antioxidants and ROS Metabolism Gene Knockouts in Neurospora Crassa [PDF]
, 2015 Previous work suggested a role of reactive oxygen species (ROS) metabolism on branch density, the statistical distribution of physical distances between branch points along a growing hypha in Neurospora. Here we report the results of experiments designed
Abduljabar, Hamzah +3 more
core +2 more sources