Results 71 to 80 of about 712,690 (299)

Circulating levels of reactive oxygen species in patients with nonproliferative diabetic retinopathy and the influence of antioxidant supplementation: 6-month follow-up [PDF]

, 2015
The aim was to evaluate circulating levels of reactive oxygen species (ROS) and changes in central macular thickness (CMT) in patients with nonproliferative diabetic retinopathy (NPDR) after antioxidant supplementation.
Carnevale, Carmela, Cutini, Alessandro, Domanico, Daniela, Fragiotta, Serena, Vingolo, Enzo Maria, Zompatori, Luigi   +5 more
core   +4 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Near-infrared uncaging or photosensitizing dictated by oxygen tension

Nature Communications, 2016
The generation of reactive oxygen species (ROS) in photodynamic cancer treatments is limited by low intraturmoural oxygen availability. Here the authors show that irradiation of a silicon phthalocyanine leads to uncaging of a biologically active molecule
Erin D. Anderson, Alexander P. Gorka, Martin J. Schnermann   +2 more
doaj   +1 more source

Reactive Oxygen Species on the Early Earth and Survival of Bacteria [PDF]

, 2011
An oxygen-rich atmosphere appears to have been a prerequisite for complex, multicellular life to evolve on Earth and possibly elsewhere in the Universe. However it remains unclear how free oxygen first became available on the early Earth.
Balk, Melikea, Freund, Friedemann, Mason, Paul, Rothschild, Lynn, Smidt, Hauke, Stams, Alfons J. M.   +5 more
core   +1 more source

Cellular death, reactive oxygen species (ROS) and diabetic complications [PDF]

Cell Death & Disease, 2018
AbstractChronic or intermittent hyperglycemia is associated with the development of diabetic complications. Several signaling pathways can be altered by having hyperglycemia in different tissues, producing oxidative stress, the formation of advanced glycation end products (AGEs), as well as the secretion of the pro-inflammatory cytokines and cellular ...
Volpe, Caroline Maria Oliveira, Villar-Delfino, Pedro Henrique, dos Anjos, Paula Martins Ferreira, Nogueira-Machado, José Augusto   +3 more
openaire   +2 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Oxidative Stress in Renal Health

Antioxidants
Oxidative stress is caused by the increase in reactive oxygen species (ROS) and reactive nitrogen species (RNS) inside cells [...]
Ana Cristina Simões e Silva
doaj   +1 more source

Reduced antioxidant capacity and diet-induced atherosclerosis in uncoupling protein-2-deficient mices⃞

Journal of Lipid Research, 2009
Vascular dysfunction in response to reactive oxygen species (ROS) plays an important role in the development and progression of atherosclerotic lesions. In most cells, mitochondria are the major source of cellular ROS during aerobic respiration.
Fatiha Moukdar, Jacques Robidoux, Otis Lyght, Jingbo Pi, Kiefer W. Daniel, Sheila Collins   +5 more
doaj   +1 more source

Effect of Acupuncture on Oxidative Stress Induced by Cerebral Ischemia-Reperfusion Injury

Antioxidants, 2020
In this article, we review how acupuncture regulates oxidative stress to prevent ischemia−reperfusion injury. We electronically searched databases, including PubMed, Clinical Key and the Cochrane Library, from their inception to November 2019 by ...
Chao-Hsien Chen, Ching-Liang Hsieh
doaj   +1 more source

Rac1 drives intestinal stem cell proliferation and regeneration [PDF]

, 2013
Adult stem cells are responsible for maintaining the balance between cell proliferation and differentiation within self-renewing tissues. The molecular and cellular mechanisms mediating such balance are poorly understood.
Alessandro Scopelliti, Amcheslavsky, Ashton, Biteau, Brand, Buchon, Buchon, Choi, Cordero, el Marjou, Ellenbroek, Hochmuth, Ito, Jiang, Julia Cordero, Kevin Myant, Kitagishi, Marcos Vidal, Micchelli, Miyamoto, Myant, Ohlstein, Owen Sansom, Owusu-Ansah, Radtke, Sara Haque, Tothova, Tsatmali, Walmsley   +28 more
core   +1 more source