Results 91 to 100 of about 2,835,706 (332)

Life events and hemodynamic stress reactivity in the middle-aged and elderly [PDF]

, 2005
Recent versions of the reactivity hypothesis, which consider it to be the product of stress exposure and exaggerated haemodynamic reactions to stress that confers cardiovascular disease risk, assume that reactivity is independent of the experience of ...
Aiken L. S., Allen M. T., Benschop R. J., Boyce W. T., Brown G. W., Cacioppo J. T., Carroll D., Carroll D., Carroll D., Everson S. A., Eysenck H. J., Lepore S. J., Light K. C., Linden W., Lynch J. W., Manuck S. B., Markovitz J. H., Matthews K. A., Matthews K. A., Musante L., Phillips A. C., Pike J. L., Registrar General, Treiber F. A., Treiber F. A., West S. G.   +25 more
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

New Derivatives of Oleanolic Acid: Semi-Synthesis and Evaluation of Their Anti-15-LOX, Anti-α-Glucosidase and Anticancer Activities and Molecular Docking Studies

Chemistry
A novel series of oleanolic acid (OA, 1) derivatives incorporating phenolic and coumarin moieties were synthesized. This acid was extracted from olive pomace (Olea europaea L.) using an ultrasound-assisted method.
Nahla Triaa, Salma Jlizi, Mansour Znati, Hichem Ben Jannet, Jalloul Bouajila   +4 more
doaj   +1 more source

Atmospheric chemistry of bioaerosols: heterogeneous and multiphase reactions with atmospheric oxidants and other trace gases. [PDF]

, 2016
Advances in analytical techniques and instrumentation have now established methods for detecting, quantifying, and identifying the chemical and microbial constituents of particulate matter in the atmosphere.
Estillore, Armando D, Grassian, Vicki H, Trueblood, Jonathan V   +2 more
core   +2 more sources

Modulation of astrocyte reactivity improves functional deficits in mouse models of Alzheimer’s disease

Acta Neuropathologica Communications, 2018
Astrocyte reactivity and neuroinflammation are hallmarks of CNS pathological conditions such as Alzheimer’s disease. However, the specific role of reactive astrocytes is still debated.
K. Ceyzériat, L. Ben Haim, Audrey Denizot, Dylan Pommier, Marco Matos, Océane Guillemaud, M. Palomares, Laurene Abjean, Fanny Petit, P. Gipchtein, M. Gaillard, M. Guillermier, Suéva Bernier, Mylène Gaudin, G. Aurégan, Charlène Joséphine, N. Déchamps, J. Véran, Valentin C Langlais, K. Cambon, A. Bemelmans, J. Baijer, G. Bonvento, M. Dhenain, J. Deleuze, S. Oliet, E. Brouillet, P. Hantraye, Maria-Angeles Carrillo-de Sauvage, R. Olaso, A. Panatier, C. Escartin   +31 more
semanticscholar   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Surface reactivity of amphibole asbestos. A comparison between crocidolite and tremolite [PDF]

, 2017
Among asbestos minerals, fibrous riebeckite (crocidolite) and tremolite share the amphibole structure but largely differ in terms of their iron content and oxidation state. In asbestos toxicology, iron-generated free radicals are largely held as one of
Andreozzi, Giovanni B., Corazzari, Ingrid, Pacella, Alessandro, Tomatis, Maura, Turci, Francesco   +4 more
core   +3 more sources

Molecular Electron Density Theory: A Modern View of Reactivity in Organic Chemistry

Molecules, 2016
A new theory for the study of the reactivity in Organic Chemistry, named Molecular Electron Density Theory (MEDT), is proposed herein. MEDT is based on the idea that while the electron density distribution at the ground state is responsible for physical ...
L. Domingo
semanticscholar   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source