Results 41 to 50 of about 46,449 (257)

DESARROLLO DE LOS ÍNDICES DE PODER ELECTROFÍLICO Y NUCLEOFÍLICO DENTRO DEL MARCO CONCEPTUAL DE LA TEORÍA DEL FUNCIONAL DE LA DENSIDAD

Química Nova
In this work, the electrophilic and nucleophilic power indices were developed in the basis of canonical and grand canonical ensembles respectively, also local versions of these indices has been derived in analogy to philicity concept by Chattaraj. It can
Said F. Figueredo, Manuel S. Páez, Jong-Won Song   +2 more
doaj   +1 more source

Influence of Reactive and Maximum Strength Indicators on Sprint Performance

Journal of Strength and Conditioning Research, 2019
Abstract Healy, R, Smyth, C, Kenny, IC, and Harrison, AJ. Influence of reactive and maximum strength indicators on sprint performance. J Strength Cond Res 33(11): 3039–3048, 2019—The primary aim of this study was to assess the relationship between reactive and maximal strength measures with 40 m sprint performance and mechanical properties ...
Healy, Robin, Smyth, Carol, Kenny, Ian C., Harrison, Andrew J.   +3 more
openaire   +3 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Reactivity Improvement of Bamboo Dissolving Pulp by Xylanase Modification

BioResources, 2015
A high reactivity is an essential prerequisite for dissolving pulp. In this study, xylanase modification to increase the reactivity of bamboo dissolving pulp was investigated.
Chaojun Wu, ShuFang Zhou, Ronggang Li, Daiqi Wang, Chuanshan Zhao   +4 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

The Perceived Stress Reactivity Scale for Adolescent Athletes: Translation, Validity and Reliability Study

Türk Spor ve Egzersiz Dergisi, 2019
This study aims to analyze the validity and reliability of The Perceived Stress Reactivity Scale for Adolescent Athletes. 220 athletes including 111 females and 109 males from seventeen different sports branches participated in the study. The age mean of
Ender Şenel, Mevlüt Yıldız, Nazmi Bayköse   +2 more
doaj   +1 more source

Changes in Vascular and Metabolic Reactivity as Indices of Ischaemia in the Penumbra [PDF]

Journal of Cerebral Blood Flow & Metabolism, 1988
The reactivities of cerebral cortical blood flow (hydrogen clearance) and of compensated NADH fluorescence to local cortical electrical stimulation were examined on the marginal gyrus before and after transorbital occlusion of the middle cerebral artery in cats. Prestimulus cerebral blood flow (CBF) was 38.2 ± 12.9 (SD) ml 100 g
A J, Strong, G, Gibson, S A, Miller, G S, Venables   +3 more
openaire   +2 more sources