Results 91 to 100 of about 4,441,099 (286)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Reader-Response Criticism in the Teaching of Poetry [PDF]

open access: yes, 1992
The focus of this project is on the use of the reader-response orientation in the development of a poetry unit for grade seven. The reader-response orientation is a literary theory which suggests that the meaning of any literary work is the result of ...
Paas, Steve
core  

A READER RESPONSE APPROACH IN COLLABORATIVE READING PROJECTS TO FOSTER CRITICAL THINKING SKILLS

open access: yesLLT Journal: A Journal on Language and Language Teaching, 2019
Reading has become a major concern of EFL educators. Reading does not only help students learn foreign languages, but it is also believed that it has a strong link with critical thinking skills.
Truly Almendo Pasaribu   +1 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

Between Fact and Fiction in Dan Brown’s the Da Vinci Code (2003) : Reader Response Analysis

open access: yesTell-us Journal, 2018
The research’s purpose is to analyze reader response strategies which are used by readers to respond Dan Brown’s the Da Vinci Code novel. The objectives of the study are to know kind of reader response strategies that are applied by the readers to ...
Wahyu Unggul Widodo
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Reader-to-Leader Framework (RtLF).

open access: yes, 2019
Reader-to-Leader Framework (RtLF).
Simon L. Jones (6725672)   +3 more
core   +1 more source

INVESTIGATING EFL LEARNERS’ INQUIRY PROCESS IN ACADEMIC READING

open access: yesELT Echo: The Journal of English Language Teaching in Foreign Language Context, 2019
For a higher-order comprehension, academic reading class at IAIN Syekh Nurjati Cirebon is designed to develop the EFL learners’ critical reading, and to draw their awareness to the relationship between reading and writing.
Hendi hidayat, sumadi sumadi
doaj   +1 more source

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