Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
INVESTIGATING EFL LEARNERS’ INQUIRY PROCESS IN ACADEMIC READING
ELT Echo: The Journal of English Language Teaching in Foreign Language Context, 2019 For a higher-order comprehension, academic reading class at IAIN Syekh Nurjati Cirebon is designed to develop the EFL learners’ critical reading, and to draw their awareness to the relationship between reading and writing.
Hendi hidayat, sumadi sumadi
doaj +1 more source
Reader Response: Clinical Subgroups and Factors Associated With Progression in Patients With Inclusion Body Myositis. [PDF]
Neurology, 2023 Stenzel W, Goebel HH, Kleefeld F.
europepmc +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Let Seizing Truths Lie: Witnessing “Factions” in Lauren Slater’s Lying
Humanities, 2017 In her memoir, Lying (2000), Lauren Slater fabricates most of her life narrative. Her text frustrates those who resent the combined fact and fiction—or “faction”—that she spins. This readerly response is understandable.
Eden Wales Freedman
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
The Effect of the Reader-Response Approach on Enhancing English Reading Comprehension Skills of Secondary Stage Students [PDF]
مجلة العلوم التربوية بکلية التربية، جامعة الغردقةThe present study aimed at exploring the impact of using the reader-response approach on enhancing some English reading comprehension skills of secondary stage students. The quasi-experimental one group pretest-posttest design was adopted.
ا.د. عيد عبدالواحد علي درويش +3 more
doaj +1 more source
Reader Response: Teaching NeuroImage: Partially Reversible Widespread Leukoencephalopathy Associated With Atypical Hemolytic Uremic Syndrome. [PDF]
Neurology, 2023 Graber J.
europepmc +1 more source
Reader-response criticism: Reader, response and interpretation1
, 2019 © 2019 Karadeniz Technical University. All rights reserved.Reader-response criticism is not a conceptually unified critical position. Its theory is instead associated with the work of critics who use the reading process and response to centralize the ...
BAKTIR, HASAN
core
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source