Results 51 to 60 of about 956,174 (309)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Літературна критика Стенлі Фіша: від афективної стилістики до теорії «інтерпретаційних спільнот» [PDF]

open access: yes, 2014
Стенлі Ю.Фіш (1938 - ) як представник теорії читацького відгуку у США (кінець 1960-х – поч. 80-х) один з перших кинув виклик авторитетності принципіальної доктрини «нової критики» – т.зв. «афективної помилки».
Анісімова, Людмила Вікторівна
core  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Portrayal of Female Characters in Train to Pakistan: An anti-feminist and Reader-Response Perspective

open access: yesUniversity of Chitral Journal of Linguistics and Literature, 2022
The study aims at exploring the portrayal of women in “Train to Pakistan” by Khushwant Singh. It is aimed to understand the way the female characters are represented as seductress, femme fatal, and as the angels by a male author through the lens of ...
Zarina Qasim, Dr., Asifa Qasim, Dr.
doaj  

Theoretical Foundations of a Study Examining Adolescent Literature and Rape Myth Acceptance [PDF]

open access: yes, 2013
Adolescents are at the greatest risk for victimization and perpetration of sexual assault. This paper examines the current trends in literacy education which marginalize aesthetic reading experiences and using reader response theory, and argues that ...
Malo-Juvera, Victor
core  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Wolfgang Iser. Towards Literary Anthropology. Introduction

open access: yesEnthymema, 2017
In this article you find the editorial remarks of this special issue on “Wolfgang Iser. Towards Literary Anthropology”, edited by Laura Lucia Rossi. Alongside introducing the content of the issue, the author reflects on Wolfgang Iser’s influence and ...
Laura Lucia Rossi
doaj   +1 more source

Future Scenario: Praxis in Critical Race Theory in Higher Education and Student Affairs [PDF]

open access: yes, 2019
Critical Race Theory (CRT) evolved as a response to the lack of change in racial disparities within the United States jurisprudence. This article provides a historical understanding of CRT, beginning with a synopsis of the tenets that form part of CRT ...
Hiraldo, Payne
core   +1 more source

Practical jokes: don Delillo´s ratner´s star and literary games [PDF]

open access: yes, 2018
“Literary games” are strategies employed by writers to draw attention to, to disrupt, and even to subvert the conventions of literary production and reading.
Pritchard, Simon J.
core   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

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