Results 91 to 100 of about 832,988 (212)

Training on PD-L1 scoring in non-small cell lung cancer with high intra- and inter-reader agreement: results of a worldwide microscopic/digital image-based training of 751 pathologists. [PDF]

Br J Biomed Sci
Bänfer G, Diezko R, Oberthür R, Kumar GL, Rüschoff J, Schildhaus HU, Jasani B.   +6 more
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Artificial intelligence-assisted detection of challenging ischemic stroke on diffusion-weighted imaging: a reader study. [PDF]

Front Neurol
Jeong Y, Ryu WS, Kim BJ, Choi BS, Kim JH, Sunwoo L.   +5 more
europepmc   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Impact of reader experience on the time-saving potential of a novel computer-aided tool for Ann Arbor staging of pediatric hodgkin lymphoma. [PDF]

Front Nucl Med
Vasyliv I, Barrow MJ, Baratto L, Kim HG, von Krüchten VR, Lokesha YU, Sarrami AH, Moeremans M, Guja KE, Hawk KE, Daldrup-Link HE.   +10 more
europepmc   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

ROI-guided virtual narrow band imaging for laryngeal cancer screening. [PDF]

iScience
Huang JL, Zhu JQ, Zhao YD, Li LJ, Wang ML, Luo XS, Zhen WT, Zhang HJ, Wang JH, Zhang YH, Liu L, Zhang Y, Liu Y, Ni XG.   +13 more
europepmc   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Fiber-optic fluorescence reader for multiplex point-of-care monitoring. [PDF]

Biomed Opt Express
Reimer V, Ctistis G, Fedorov K, Guehlke P, Waltermann C, Al-Bar H, Theodoridis D, Schröder P, Wackerbarth H, Perl T, Eickel I, Wagemann-Süss M, Streit F, Schippers W, Mehren A, Koch J.   +15 more
europepmc   +1 more source