Results 81 to 90 of about 3,551,293 (296)

Moving toward an atomistic reader model [PDF]

open access: yes, 2005
With the move to recording densities up to and beyond 1 Tb/in/sup 2/, the size of read elements is continually reducing as a requirement of the scaling process.
Boerner, E.D.   +4 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Littérature numérique pour jeune public : de quelques tendances de l’offre éditoriale contemporaine

open access: yesStrenae, 2015
The emergence of digital children’s literature has not yet been analyzed from a literary point of view. The emergence of new formats that depart from picture book and illustrated book imitation can however destabilize typical educational reference points
Anne-Marie Petitjean
doaj   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

open access: yesMolecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli   +7 more
wiley   +1 more source

Reader Contact in Advertising Discourse [PDF]

open access: yes, 2010
To establish physical, emotional, and mental contact with the reader, press advertising writers use a variety of linguistic and paralinguistic techniques which deal with pictures, type and size of letters, the properties and relations of objects and ...
Котнюк, Л. Г.
core  

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

open access: yesMolecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta   +10 more
wiley   +1 more source

Wireless Chipless System for Humidity Sensing

open access: yesSensors, 2018
This work describes a fully wireless sensory system where a chipless strategy is followed in the sensor part. Alternatively, to characterize only the sensing element, we present the response of the reader antenna when the sensing element is placed in its
José F. Salmerón   +5 more
doaj   +1 more source

The Gospels and the Reader [PDF]

open access: yes, 2006
From at least the eighteenth to the mid-twentieth century the prevailing understanding of history and of texts and their meaning was almost exclusively object-centred.
Schneiders, Sandra Marie
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Redefining Media Agendas: Topic Problematization in Online Reader Comments

open access: yesMedia and Communication, 2019
Media audiences representing a significant portion of the public in any given country may hold opinions on media-generated definitions of social problems which differ from those of media professionals. The proliferation of online reader comments not only
Olessia Koltsova, Oleg Nagornyy
doaj   +1 more source

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