Results 71 to 80 of about 3,551,293 (296)
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Binary fluid amplifier solves stability and load problems [PDF]
, 1966 Digital fluid amplifier has load intensity, high stability, and operates at low reynolds numbers. It contains specially designed nozzles to provide uniform exit-velocity profiles and to ensure jets of low ...
Larkin, B. D., Reader, T. D.
core +1 more source
The Act of Fictional Communication in a Hermeneutic Pragmatics [PDF]
, 2012 This paper is concerned with fictional communication, as the act of an author in relation to a reader. Fictional discourse exhibits certain complexities that are not observable in other forms of discourse.
Wood Tahir
core +2 more sources
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Flexible Learning Spaces Evaluation Report [PDF]
, 2013 City University, London is tackling the challenge of ensuring the learning spaces provided are able to meet the anticipated increase in technology usage and prevalent pedagogies.
Bullimore, A., Reader, K., Sultany, A.
core
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Author and reader in Instructions for use [PDF]
, 1997 Instructions for use should not be seen as merely instrumental-they should also persuade the reader to read the text and to act accordingly. Moreover, they should establish a positive image of the product and the manufacturer. In this paper, a collection
Steehouder, Michael F.
core +3 more sources
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Retrospective Reader for Machine Reading Comprehension
, 2020 Machine reading comprehension (MRC) is an AI challenge that requires machine to determine the correct answers to questions based on a given passage. MRC systems must not only answer question when necessary but also distinguish when no answer is available
Yang, Junjie +2 more
core +1 more source