Results 101 to 110 of about 1,806,462 (261)
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann +11 morewiley +1 more sourcePAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann +10 morewiley +1 more sourceAction to protect the independence and integrity of global health research
BMJ Global Health, 2019 David Sanders, Lu Gram, Benjamin Tsofa, Johanne Sundby, Tolib Mirzoev, Kristine Bærøe, Ole Frithjof Norheim, Ejemai Eboreime, Valéry Ridde, Kristine Husøy Onarheim, Emily Mendenhall, Vladimir S Gordeev, Tanya Doherty, Stephen Taylor, David Peters, Shariful Islam, Madhukar Pai, Elysée Nouvet, Francesca L Cavallaro, Shafiu Mohammed, Sassy Molyneux, Karl Blanchet, Janice E Graham, Kayvan Bozorgmehr, David McCoy, Joel Lexchin, Anna-Karin Hurtig, Asha George, Rachel Chapman, Loveday Penn-Kekana, Katerini T Storeng, Dina Balabanova, Veronique Filippi, Sidsel Roalkvam, Grace Akello, Melissa Parker, Jennifer Palmer, Ibukun Abejirinde, Babatope Adebiyi, Clara Affun-Adegbulu, Jhon Álvarez Ahlgren, Ayesha Ahmad, Sameh Al-Awlaqi, Zongo Aloys, Gianna Gayle Amul, Muhammad Asaduzzaman, Akeza Awealom Asgedom, Bouchra Assarag, Nicole Atchessi, Salla Atkins, Okikiolu Badejo, Bailah Molleh, Alessandra Bazzano, Dominique P Béhague, Uli Beisel, Loubna Belaid, Sarah Bernays, Shafi Bhuiyan, Olivia Biermann, Harriet Birungi, Astrid Blystad, Oriane Bodson, Emmanuel Bonnet, Shibaji Bose, Michelle Brear, Rochelle Burgess, Jens Byskov, Séverine Carillon, Sophie Chabeda, Clare Chandler, Francis F Chikuse, Juliana Iwu Chinwe, Beniamino Cislaghi, Svea Closser, Christopher J Colvin, Jenny Cresswell, Fabiana da Cunha Saddi, Judith Daire, Sarah Dalglish, Vincent de Brouwere, Jean-Pierre Olivier de Sardan, Thérèse Delvaux, Annabel Desgrées du Loû, Brahima A Diallo, Aïssa Diarra, Justin Dixon, Alexandre Dumont, Beth Engelbrecht, Susan Erikson, Adama Faye, Sara Fischer, Florence Fournet, Ashley M Fox, Joel Msafiri Francis, Lara Gautier, Lucy Gilson, Sarah Gimbel, Jeff Glenn, Unni Gopinathan, Christoph Gradmann, Giulia Greco, Karen Grepin, Anne Guichard, Pragya Tiwari Gupta, Viveka Guzman, Marte E S Haaland, Anna Häggblom, Amy Hagopian, Karin Hammarberg, Pascal Handschumacher, Katrina Hann, Marie Hasselberg, Natasha Howard, Sameera Hussain, Eleanor Hutchinson, Ezirim Idoteyin, Jennifer J Infanti, Rachel Irwin, Taufique Joarder, Preethi John, Ermel Johnson, Mira Johri, Judith Justice, Charles Kaboré, Kadidiatou Kadio, Matthieu Kamwa, Ann H Kelly, Nora Kenworthy, Sonja Kittelsen, Maren Olene Kloster, Emily Kocsis, Pratap Kumar, Arush Lal, Isabelle Lange, Heather Lanthorn, Frederic Le Marcis, Shelley Lees, Ann Louise Lie, Gojjam Limenih, Isabel Litwin-Davies, Charles Clarke Lodda, Knut Lönnroth, John Manton, Anatole Manzi, Mehr Manzoor, Robert Marten, Mitsuaki Matsui, Allan Mbewe, Esther Mc Sween-Cadieux, Linsey McGoey, Desmond McNeill, Claudio A Méndez, Karen Marie Moland, Zubia Mumtaz, Susan Fairley Murray, Devaki Nambiar, Erica Nelson, Claudia Nieto-Sanchez, Francis Obare, Vincent Okungu, Marit Tolo Østebø, Fatoumata Ouattara, Sachiko Ozawa, Ligia Paina, Rakesh Parashar, Elisabeth Paul, Koen Peeters, Cédric Pennetier, James Pfeiffer, Hanneke Pot, N S Prashanth, Robyn Preston, Antoine de Bengy Puyvallee, Annisa Rahmalia, Simon Reid-Henry, Daniela C Rodríguez, Maya Ronse, Emma Sacks, Oumar Mallé Samb, Eric Sarriot, Inger Brummenæs Scheel, Thomas Schwarz, Kerry Scott, Janet Seeley, Nadine Seward, Geordan Shannon, Jessica Shearer, Katharine Shelley, Kenneth Sherr, Jeremey Shiffman, Frédéric Simard, Neha S Singh, Werner Soors, Rusla Anne Springer, Adrienne Strong, Moses Tetui, Stephanie M Topp, Anne-Marie Turcotte-Tremblay, Chi-Chi Undie, Sara Van Belle, Godelieve Van Heteren, André Janse van Rensburg, Veena Sriram, Sridhar Venkatapuram, Bradley H Wagenaar, Lauren Wallace, David R Walugembe, Oghenebrume Wariri, Alan OBE Whiteside, Bereket Yakob, Scholastica Zakayo, Tony Zitti, Anthony Zwi +212 moredoaj +1 more sourceSpatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours +11 morewiley +1 more sourceInhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli +10 morewiley +1 more sourceIn vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer +8 morewiley +1 more source
