Results 101 to 110 of about 1,154,560 (308)
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
De leer, serie radial sobre la promoción de la lectura
Revista Interamericana de Bibliotecología, 2008 Presenta la serie radial De leer, un viaje por la promoción de la lectura, como producto derivado delproyecto de investigación aplicada, realizado en el formato de radio cultural y educativa por laEscuela Interamericana de Bibliotecología, La Emisora ...
Alejandro Uribe-Tirado +2 more
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Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Du lyrisme au lecteur : le désir de contemporanéité chez João Cabral et Ana Cristina Cesar
Brésil(s)This article proposes a reading of João Cabral de Melo Neto's essays, in particular « Poesia e composição », highlighting the concepts of « norm » and « reader ».
Marcos Siscar
doaj +1 more source
, 2004 The paper develops the functional dimension of the procedural model that explains how a digital literary work differs in its own from a classical print work. Generally the differences are considered as the introduction of the interactivity and the hypertextual dimension.
openaire +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Using E-Z reader to examine the consequences of fixation-location measurement error
, 2015 There is an ongoing debate about whether fixation durations during reading are only influenced by the processing difficulty of the words being fixated (i.e., the serial-attention hypothesis) or whether they are also influenced by the processing ...
Reichle, Erik D., Drieghe, Denis
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Библиосфера, 2015 The paper analyzes information requirements and interests of higher school library users. It presents services of a private office for a student, a teacher and administrative personnel of higher education institution available at the Siberian Federal ...
R. A. Baryshev, O. I. Babina
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