Results 101 to 110 of about 3,533,611 (280)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Acercamiento al estado actual de la promoción de la lectura en la biblioteca pública en Colombia
Revista Interamericana de Bibliotecología, 2008 Se presenta el resultado de la investigación sobre las actividades de promoción de la lectura que realizala biblioteca pública en Colombia. Indaga acerca de la presencia de la biblioteca en la cultura escrita yel rol desempeñado por las iniciativas de ...
Didier Álvarez Zapata +3 more
doaj
Readers’ acceptance of Ian McEwan novels in Mainland China: a systematic review
RUDN Journal of Studies in Literature and JournalismWith the accelerated development of globalisation and the deepening of cultural exchanges, cross-cultural translation and literary reception have become important topics in contemporary literary studies. This review aims to explore readers’ acceptance of
Wen Nie +3 more
doaj +1 more source
Kinesiology, 2005 It is a pleasure to be able to inform you that out journal Kinesiology has undergone a serious and a very strict assessment by the Ministry of Science, Education and Sport of the Republic of Croatia and that according to all the applied bibliometric criteria it received high marks and consequently is ranked fifth on the scale of approximately forty ...
openaire +7 more sources
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Binary fluid amplifier solves stability and load problems [PDF]
, 1966 Digital fluid amplifier has load intensity, high stability, and operates at low reynolds numbers. It contains specially designed nozzles to provide uniform exit-velocity profiles and to ensure jets of low ...
Larkin, B. D., Reader, T. D.
core +1 more source
, 2004 The paper develops the functional dimension of the procedural model that explains how a digital literary work differs in its own from a classical print work. Generally the differences are considered as the introduction of the interactivity and the hypertextual dimension.
openaire +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Method and apparatus for making curved reflectors Patent [PDF]
, 1970 Fabrication of curved reflector segments for solar ...
Reader, A. F. +2 more
core +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source