Results 71 to 80 of about 1,487,886 (323)

Identification of functional and diverse circulating cancer‐associated fibroblasts in metastatic castration‐naïve prostate cancer patients

Molecular Oncology, EarlyView.
Cancer‐associated fibroblasts (CAFs) promote cancer growth, invasion (metastasis), and drug resistance. Here, we identified functional and diverse circulating CAFs (cCAFs) in patients with metastatic prostate cancer (mPCa). cCAFs were found in higher numbers and were functional and diverse in mPCa patients versus healthy individuals, suggesting their ...
Richell Booijink, Leon W. M. M. Terstappen, Eshwari Dathathri, Khrystany Isebia, Jaco Kraan, John Martens, Ruchi Bansal   +6 more
wiley   +1 more source

The “Anchor Shape” Technique for Long Head of the Biceps Tenotomy to Avoid the Popeye Deformity

Arthroscopy Techniques, 2013
Surgical options for symptomatic pathologies of the long head of the biceps (LHB) include tenotomy and tenodesis. Tenotomy is surgically simple and quick, does not require immobilization, and avoids implant complications.
A. Ali Narvani, F.R.C.S.(Orth&Tr), Ehud Atoun, M.D., Alexander Van Tongel, M.D., Giuseppe Sforza, M.D., Ofer Levy, M.D., M.Ch.(Orth), F.R.C.S   +4 more
doaj  

Connecting Physical and Socio‐Economic Spaces for Multi‐Scale Urban Modelling: A Dataset for London

Geoscience Data Journal
Versatile approaches for urban modelling need to simultaneously consider the physical characteristics of a city (urban form) and urban function as a manifestation of economically, socially, and culturally motivated human activities.
Denise Hertwig, Megan McGrory, Matthew Paskin, Yiqing Liu, Samuele Lo Piano, Heidi Llanwarne, Stefán T. Smith, Sue Grimmond   +7 more
doaj   +1 more source

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

Molecular Oncology, EarlyView.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi, Jérome Vialaret, Christophe Hirtz, Catherine Alix‐Panabières   +3 more
wiley   +1 more source

Sequence assembly from corrupted shotgun reads [PDF]

arXiv, 2016
The prevalent technique for DNA sequencing consists of two main steps: shotgun sequencing, where many randomly located fragments, called reads, are extracted from the overall sequence, followed by an assembly algorithm that aims to reconstruct the original sequence.
arxiv  

Clinical applications of next‐generation sequencing‐based ctDNA analyses in breast cancer: defining treatment targets and dynamic changes during disease progression

Molecular Oncology, EarlyView.
Circulating tumor DNA (ctDNA) offers a possibility for different applications in early and late stage breast cancer management. In early breast cancer tumor informed approaches are increasingly used for detecting molecular residual disease (MRD) and early recurrence. In advanced stage, ctDNA provides a possibility for monitoring disease progression and
Eva Valentina Klocker, Samantha Hasenleithner, Rupert Bartsch, Simon P. Gampenrieder, Daniel Egle, Christian F. Singer, Gabriel Rinnerthaler, Michael Hubalek, Katja Schmitz, Zsuzsanna Bago‐Horvath, Andreas Petzer, Sonja Heibl, Ellen Heitzer, Marija Balic, Michael Gnant   +14 more
wiley   +1 more source

Linear read-once and related Boolean functions [PDF]

arXiv, 2018
It is known that a positive Boolean function f depending on n variables has at least n + 1 extremal points, i.e. minimal ones and maximal zeros. We show that f has exactly n + 1 extremal points if and only if it is linear read-once. The class of linear read-once functions is known to be the intersection of the classes of read-once and threshold ...
arxiv  

Circulating tumor cells: advancing personalized therapy in small cell lung cancer patients

Molecular Oncology, EarlyView.
Small cell lung cancer (SCLC) is an aggressive form of lung cancer that spreads rapidly to secondary sites such as the brain and liver. Cancer cells circulating in the blood, “circulating tumor cells” (CTCs), have demonstrated prognostic value in SCLC, and evaluating biomarkers on CTCs could guide treatment decisions such as for PARP inhibitors ...
Prajwol Shrestha, Steven Kao, Veronica K. Cheung, Wendy A. Cooper, Nico van Zandwijk, John E. J. Rasko, Dannel Yeo   +6 more
wiley   +1 more source

Diagnosing Horizontal and Inter-Channel Observation Error Correlations for SEVIRI Observations Using Observation-Minus-Background and Observation-Minus-Analysis Statistics

Remote Sensing, 2016
It has been common practice in data assimilation to treat observation errors as uncorrelated; however, meteorological centres are beginning to use correlated inter-channel observation errors in their operational assimilation systems. In this work, we are
Joanne A. Waller, Susan P. Ballard, Sarah L. Dance, Graeme Kelly, Nancy K. Nichols, David Simonin   +5 more
doaj   +1 more source

KRAS and GNAS mutations in cell‐free DNA and in circulating epithelial cells in patients with intraductal papillary mucinous neoplasms—an observational pilot study

Molecular Oncology, EarlyView.
This study demonstrates that KRAS and GNAS mutations are more prevalent in patients with resected intraductal papillary mucinous neoplasms (IPMN) compared to those under clinical surveillance. GNAS mutations significantly differ between the two patient cohorts, indicating that their absence may serve as a potential biomarker to support conservative ...
Christine Nitschke, Marie Tölle, Philipp Walter, Kira Meißner, Mara Goetz, Jolanthe Kropidlowski, Andreas W. Berger, Jakob R. Izbicki, Felix Nickel, Thilo Hackert, Klaus Pantel, Harriet Wikman, Faik G. Uzunoglu   +12 more
wiley   +1 more source