Results 71 to 80 of about 6,049,564 (332)
Thunderstorm occurrence at ten sites across Great Britain over 1884–1993
Geoscience Data Journal, 2019 The UK Met Office's Daily Weather Reports (DWR) contain extensive logs of UK thunderstorm activity. To date, only a very small fraction of these data have been digitized as part of the MIDAS dataset, and exclusively after 1950. Using the recently‐scanned
Maria Valdivieso +5 more
doaj +1 more source
The Indian Easterly Jet During the Pre‐Monsoon Season in India
Geophysical Research Letters, 2023 We identify for the first time an Indian Easterly Jet (IEJ) in the mid‐troposphere during the pre‐monsoon using reanalysis data. The IEJ is weaker and smaller than the African Easterly Jet over West Africa, with a climatological location of 10°N, 60–90°E,
Hannah L. Croad +4 more
doaj +1 more source
FEBS Letters, EarlyView.We investigated the seeded assembly of 0N3R tau and two variants, C322A and C322S, designed to model the mutation landscape at residue 322, using Alzheimer's disease brain homogenates in a real‐time quaking‐induced conversion (RT‐QuIC) assay. The C322A variant formed filaments that partially resembled the paired helical filament (PHF) structure ...
Alessia Santambrogio +9 more
wiley +1 more source
Structural dynamics of the plant hormone receptor ETR1 in a native‐like membrane environment
FEBS Letters, EarlyView.The present study unveils the structural and signaling dynamics of ETR1, a key plant ethylene receptor. Using an optimized nanodisc system and solution NMR, we captured full‐length ETR1 in a native‐like membrane environment. Our findings reveal dynamic domain uncoupling and Cu(I)‐induced rigidification, providing the first evidence of metal‐triggered ...
Moritz Lemke +2 more
wiley +1 more source
FEBS Letters, EarlyView.Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer +10 more
wiley +1 more source
A global climatology of sting-jet extratropical cyclones [PDF]
Weather and Climate DynamicsSting jets have been identified in the most damaging extratropical cyclones impacting northwest Europe. Unlike the cold conveyor belt and other long-lived cyclone wind jets, sting jets can lead to regions of exceptionally strong near-surface winds and ...
S. L. Gray +6 more
doaj +1 more source
FEBS Letters, EarlyView.Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican +7 more
wiley +1 more source
Hypochloraemia and 30 day readmission rate in patients with acute decompensated heart failure
ESC Heart Failure, 2020 Aims Despite recent advances in guideline‐directed therapy, rehospitalization rates for acute decompensated heart failure (ADHF) remain high. Recently published studies demonstrated the emerging role of hypochloraemia as a predictor of poor outcomes in ...
Roman Marchenko +7 more
doaj +1 more source
Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells
FEBS Letters, EarlyView.Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura +8 more
wiley +1 more source