Results 121 to 130 of about 908,902 (242)
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Migrant Youths‘ Educational Achievement: The Role of Institutions [PDF]
We use 2009 Programme of International Student Assessment (PISA) data to link institutional arrangements in OECD countries to the disparity in reading, math, and science test scores for migrant and native-born students.
Deborah A. Cobb-Clark +2 more
core +3 more sources
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Evaluating the Impact of Charter Schools on Student Achievement: A Longitudinal Look at the Great Lakes States [PDF]
, 2007 This study looks at student achievement in math and reading in charter and traditional public schools over a five-year period in Illinois, Indiana, Michigan, Minnesota, Ohio, and Wisconsin.
Chris Coryn, Dawn M. Mackety, Gary Miron
core +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
THE INFLUENCE OF STUDENTS’ KNOWLEDGE IN WORD MEANING ON STUDENTS’ ACHIEVEMENT IN READING COMPREHENSION AT THE SECOND YEAR OF MA AI MERTAPADA KABUPATEN CIREBON [PDF]
, 2012 Siti Hanifah : THE INFLUENCE OF STUDENTS’ KNOWLEDGE IN WORD MEANING ON STUDENTS’ ACHIEVEMENT IN READING COMPREHENSION AT THE SECOND YEAR OF MAAI MERTAPADA KABUPATEN CIREBON. The students have problem in studying English especially in reading.
Siti Hanifah,
core
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Building 10th Grade Students’ Vocabulary through Reading the Newspaper at SMK 45 Lembang Authors
Acuity, 2020 Using newspaper either printed or online as a medium of English learning is a unique way to stimulate students’ interest in reading since most of the students at this age have dropped their interest in reading resulting their lack of English vocabulary.
Caroline V Katemba, Rafael R Parillia
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