Results 101 to 110 of about 85,909 (261)

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

Lightweight Meter Pointer Recognition Method Based on Improved YOLOv5

Sensors
In substation lightning rod meter reading data taking, the classical object detection model is not suitable for deployment in substation monitoring hardware devices due to its large size, large number of parameters, and slow detection speed, while is ...
Chi Zhang, Kai Wang, Jie Zhang, Fan Zhou, Le Zou   +4 more
doaj   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

"Exercícios de raciocínio" em três linguagens: ensino de física nas séries iniciais

Ensaio Pesquisa em Educação em Ciências, 2002
In order to study the fitness of child's tales as a Physic Teaching instrument, we elaborated a science learning activity to second grade students of an elementary public school in São Paulo city.
Maria da Conceição Barbosa Lima, Anna Maria Pessoa de Carvalho   +1 more
doaj  

Searching for the Shanghai Institute of Biological Products (SIBP) in Columbia Circle Park: the neglected socialist danwei spaces and its place memory in urban renewal

Built Heritage
No. 1262 Yan'an West Road and No. 60 Panyu Road in Shanghai were previously part of Columbia Circle, which began construction in 1924, and the base of the Shanghai Institute of Biological Products (SIBP) from 1951 to 2014.
Jiao Wu, Jingyuan Bi, Xiahong Hua, Mengyue Mei, Xiaodan Lin, Yujie Qin   +5 more
doaj   +1 more source

Reading circles and literary literacy in prison

, 2020
A leitura é uma ferramenta valiosíssima na formação do sujeito e, por esse motivo, deveria ser tratada como um direito cultural ao qual todos os cidadãos deveriam ter acesso. Contudo, não é essa a nossa realidade. Neste artigo, pretendemos elucidar a importância da leitura, bem como o modo como ela vem sendo tratada nas escolas e no ambiente carcerário.
Jorge, Patrícia Gonçalves, Cunha, Karina Zendron da, Ramos, Suelen   +2 more
openaire   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

ORGANIZATION OF READING CIRCLES IN SCHOOLS

Reading is a fundamental skill that is essential for students to develop throughout their educational careers and beyond. While reading instruction is a core component of elementary education, it is important that secondary schools also foster a culture of reading to help students continue advancing their literacy abilities. One strategy that secondary
openaire   +2 more sources

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

FEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow, Isabel Brandtjen, Yaxin Mo, Melissa Gulley, Louis Osorio, Sagar Kudchodkar, Nandita C. Jhumur, Christine C. Roberts, Lisa K. Denzin, David I. Shreiber, Biju Parekkadan, Hao Lin, Joel N. Maslow   +12 more
wiley   +1 more source