Results 101 to 110 of about 2,069,613 (288)
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Reading Circle List for 2014 [PDF]
, 2014 Reading Circle is a monthly event organised by the Faculty of Social Sciences. The objective is to inculcate the spirit of inquiry and intellectual discussion based on the readings of key texts in social sciences.
Sharifah S., Wan Ahmad
core
Augmenting and Assaying Nav1.1 Protein Quantity for Dravet Syndrome Therapy. [PDF]
Ann Clin Transl NeurolABSTRACT Dravet Syndrome (DS) is a developmental and epileptic encephalopathy predominantly caused by heterozygous loss‐of‐function variants in SCN1A, which encodes Nav1.1. Conserved upstream open reading frames (uORFs) in SCN1A were validated to regulate translation in reporter assays, demonstrating the therapeutic viability of increasing Nav1.1 from ...
Saravanan A +7 more
europepmc +2 more sources
Reading Circle Method and Its Influence on Reading Comprehension
Arab World English JournalThis study was conducted to investigate the benefits of reading circles on students’ reading comprehension skills and to determine the differences between the traditional reading method and the reading circle method. Since there is no example of such a study in Iraq, it will be a unique resource for those who will conduct studies on this subject.
openaire +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Multimodal genres in textbooks: are students being schooled for visual literacy?
Bakhtiniana: Revista de Estudos do Discurso, 2012 In this paper, we discuss some issues involved in teaching and learning reading, especially schooling in visual literacy. We seek to observe the work developed with genres that combine verbal and visual languages, found in the reading activities of two ...
Cláudia Graziano Paes de Barros +1 more
doaj
Thoughts of G. Mazzini in “The Circle of Reading” by L.N. Tolstoy
Язык и текстThanks to the earliest Russian translations of Giuseppe Mazzini’s major work, I doveri dell’uomo (The Duties of Man), L.N. Tolstoy became acquainted with the ideas of one of the leading figures of the Italian Risorgimento for whom ...
A. Cavazza
doaj +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source