Results 71 to 80 of about 3,619,309 (282)

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

open access: yesFEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Improving reading: a handbook for improving reading in key stages 3 and 4 (National Strategies: secondary) [PDF]

open access: yes, 2009
"This handbook explores what it means to be a reader and some core challenges and skills that need to be addressed in the teaching of reading. The handbook outlines a route to improvement that can be followed to ensure that all pupils make expected ...

core  

Letter processing and font information during reading: beyond distinctiveness, where vision meets design [PDF]

open access: yes, 2012
Letter identification is a critical front end of the reading process. In general, conceptualizations of the identification process have emphasized arbitrary sets of distinctive features.
A Arditi   +87 more
core   +2 more sources

Function‐driven design of a surrogate interleukin‐2 receptor ligand

open access: yesFEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang   +9 more
wiley   +1 more source

The Validation Process in the IELTS Reading Component: Reading Requirements for Preparing International Students

open access: yesJournal of Language and Education, 2018
Although IELTS is coordinated under a framework for test development and validation, there is some controversy about exam results’ correlation with students’ post-admission intellectual, academic and professional performance.
Marina Kovalenko
doaj   +1 more source

Frequency drives lexical access in reading but not in speaking: the frequency-lag hypothesis [PDF]

open access: yes, 2011
To contrast mechanisms of lexical access in production versus comprehension we compared the effects of word frequency (high, low), context (none, low constraint, high constraint), and level of English proficiency (monolingual, Spanish-English bilingual ...
Duyck, Wouter   +5 more
core   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

open access: yesFEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira   +3 more
wiley   +1 more source

The design process of a reading comprehension manual

open access: yesColombian Applied Linguistics Journal, 2015
Material design is an important part in the teaching practices. This article describes the process of material design of a foreign language (FL) reading manual for undergraduate students at Universidad de Antioquia (Medellín – Colombia). A case study was
Sergio Alonso Lopera Medina
doaj   +1 more source

Making the Invisible, Visible: RtI and Reading Comprehension

open access: yes, 2016
For the better part of a century the educational community has had increased focus on the importance of reading. The publication of Why Johnny Can\u27t Read and What You Can Do About It (Flesch, 1955) began the surge of effort to better understand the ...
Hart, Jonathan, Stebick, Divonna M.
core  

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