Results 131 to 140 of about 4,221,594 (325)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

The impact of the text and background color on the screen reading experience

Tehnički Glasnik, 2017
Everyday use of modern technologies implies the need for an optimization of readability and legibility parameters used for the reading of text on screen.
Anja Zorko, Snježana Ivančić Valenko, Damira Keček, Darijo Čerepinko, Mario Tomiša   +4 more
doaj  

The transposed word effect is consistent with serial word recognition and varies with reading speed. [PDF]

Cognition, 2023
Hossain J, White AL.
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

The Study of the Relationship of Font Size on Reading Speed and Comprehension Levels

, 2010
[[abstract]]Reading is one of the most regarded issue presently. Recently, there have been many studies to discuss the relationship between the font size and reading speed on video display terminals.
Lai Ching-Fen
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Designing a Digital Flash Reading Test for Data-Based Decisions in Inclusive Classrooms: Duration and Word Length as Difficulty-Generating-Item Characteristics

Education Sciences
Standardized assessment tools are essential for informed, data-driven decision-making. Reading speedily is a crucial early skill that all students should have the opportunity to develop in inclusive classrooms.
Judith Zellner, Nikola Ebenbeck, Markus Gebhardt   +2 more
doaj   +1 more source

Development and Validation of a Web-Based Reading Test for Normal and Low Vision Patients

Clinical Ophthalmology, 2021
Georgios Labiris,1 Eirini-Kanella Panagiotopoulou,1 Erald Duzha,2 Maria Tzinava,2 Asli Perente,1 Aristeidis Konstantinidis,1 Konstantinos Delibasis2 1Department of Ophthalmology, University Hospital of Alexandroupolis, Dragana, 68131, Alexandroupolis ...
Labiris G, Panagiotopoulou EK, Duzha E, Tzinava M, Perente A, Konstantinidis A, Delibasis K   +6 more
doaj  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

The Effect of Speed Reading Technique on Second-Grade Students’ Reading Comprehension Levels

SAGE Open
This study aims to examine the effect of speed reading techniques on second-grade students’ reading speed and reading comprehension levels. In today’s information age, improving reading skills is vital for academic and professional success. The study was
Yasin Özkara, Senem Mergen Gürses, Yasemin Bilişli   +2 more
doaj   +1 more source