Results 111 to 120 of about 9,154,217 (376)

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini   +10 more
wiley   +1 more source

Investigating Metacognitive Strategies for overcoming Barriers to Reading Comprehension: Insights from a Pakistani Context

open access: yesJournal of Language and Cultural Education, 2018
The main aim of this research was to investigate metacognitive strategies through reading comprehension practice by first year students of engineering departments.
Channa Mansoor Ahmed   +4 more
doaj   +1 more source

Academic Reading Strategies used by Leeds Metropolitan University Graduates: A Case Study

open access: yes, 2016
Academic reading is different from other forms of reading because it is complex and discipline-specific. It involves a measured, challenging, and multifaceted process in which students are dynamically engaged with a range of reading strategies.
Samira Sohail
semanticscholar   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan   +10 more
wiley   +1 more source

Promoting Strategic Readers: Insights of Preservice Teachers' Understanding of Metacognitive Reading Strategies.

open access: yes, 2016
This study focuses on preservice teachers’ metacognitive reading strategies, in particular their awareness of such strategies as a reader and future teacher in three different stages (initial, middle, and final stages) of the teacher education program ...
Yuko Iwai
semanticscholar   +1 more source

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

open access: yesMolecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu   +15 more
wiley   +1 more source

READING STRATEGIES IN EFL CLASSROOM: A THEORETICAL REVIEW

open access: yesCendekia: Jurnal Pendidikan dan Pembelajaran, 2014
Teaching reading has been long discussed in the context of English teaching curriculum in Indonesia.  The ground of English curriculum (e.g. 1984, 1994, 2004 English curriculum) lays reading as the main model of teaching English in the secondary school ...
Teguh Budiharso
doaj   +1 more source

Impact of the home literacy environment on the L1 reading frequencies of Thai university students: Implications for the learning of an L2 [PDF]

open access: yes, 2007
In the Information Age, reading is a critical skill for accessing information and updating skills. However, reluctant readership in L1 may prevent many societies from fully participating in the global community. This reluctance to read may also slow the
Ferriman, Nicholas
core  

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

open access: yesMolecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair   +17 more
wiley   +1 more source

Enhancing the Early Literacy Development of Children at Risk for Reading Difficulties [PDF]

open access: yes, 2006
This paper reviews the dynamic and interactive links between the development of children’s language phonological awareness, and reading. Some of the key issues explored are procedures to enhance children’s language development, decoding and word ...
Fielding-Barnsley, Ruth, Hays, Ian
core   +2 more sources

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