Results 131 to 140 of about 337,644 (263)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Students` awareness of reading strategies

, 2016
Bu çalışma, (a) üniversite öğrencilerinin mevcut strateji dağarcıklarını, (b)`top-down' okuma stratejileri üzerine verilen eğitimin stratejik performanslarıüzerindeki etkisini, (c) öğrencilerin okuma süreçlerinde kullanabildikleri stratejileri,ve (d) öğrencilerin bildirdikleri okuma stratejisi kullanım sıklıkları ile uygulamadakullandıkları ...
openaire   +2 more sources

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

READING, L2 READING, AND ESP READING: CONCEPTS AND STRATEGIES

Reading is a foundational component of language learning and literacy development. Its conceptualization has evolved over decades, integrating cognitive, linguistic, and sociocultural dimensions. This article synthesizes key theoretical perspectives on general reading, second language (L2) reading, and English for Specific Purposes (ESP) reading.
openaire   +2 more sources

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

An empirical study of intermediate and advanced Chinese learners of Japanese language about reading strategies based on think-aloud protocols. [PDF]

Front Psychol
Sun Y, Zhang M, Tan S.
europepmc   +1 more source

The Impact of Language Opacity and Proficiency on Reading Strategies in Bilinguals: An Eye Movement Study. [PDF]

Front Psychol, 2016
de León Rodríguez D, Buetler KA, Eggenberger N, Laganaro M, Nyffeler T, Annoni JM, Müri RM.   +6 more
europepmc   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

The impact of technostress and generative AI on EFL mathematic metacognitive reading strategies and digital classroom burnout in SDG-aligned education. [PDF]

Sci Rep
Jingjing Q, Yan Z, Xiaobing X, Li L, Nusrat A.   +4 more
europepmc   +1 more source