Results 151 to 160 of about 6,177,094 (293)

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

open access: yesMolecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh   +11 more
wiley   +1 more source

Strategies and Techniques for Teaching Children with Learning Disabilities: A Case Study of the Spring Reading Program [PDF]

open access: yes, 2015
This case study explored strategies and techniques in order to assist individuals with learning disabilities in their academic achievement. Of particular focus was how a literacy-based program, titled The Spring Reading Program, utilizes effective ...
Cowan, Hope
core  

Strategies in teaching reading: key strategies in fiction reading

open access: yes
Fiction reading plays a pivotal role in language acquisition by improving reading comprehension and fostering critical thinking. Despite its educational significance, the Swedish national tests suggest that many pupils lack basic reading comprehension skills, therefore it affects their motivation to read and their overall academic performance.
openaire   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

open access: yesMolecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu   +9 more
wiley   +1 more source

Improving children’s reading comprehension and use of strategies through computer-based strategy training

open access: yes, 2011
[[abstract]]In this study, the attention–selection–organization–integration–monitoring (ASOIM) model, revised from Mayer’s [Mayer, R. E. (1996). Learning strategies for making sense out of expository text: The SOI model for guiding three cognitive ...
Sung, Yao-Ting   +2 more
core  

Students` awareness of reading strategies

open access: yes, 2016
Bu çalışma, (a) üniversite öğrencilerinin mevcut strateji dağarcıklarını, (b)`top-down' okuma stratejileri üzerine verilen eğitimin stratejik performanslarıüzerindeki etkisini, (c) öğrencilerin okuma süreçlerinde kullanabildikleri stratejileri,ve (d) öğrencilerin bildirdikleri okuma stratejisi kullanım sıklıkları ile uygulamadakullandıkları ...
openaire   +2 more sources

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim   +17 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

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