Results 81 to 90 of about 358,190 (262)
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Small Open Reading Frames: Current Prediction Techniques and Future Prospect
, 2011 Evidence is accumulating that small open reading frames (sORF,
Chan, Wai Soon +11 more
core +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Information seeking retrieval, reading and storing behaviour of library users
, 1997 In the interest of digital libraries, it is advisable that designers be aware of the potential behaviour of the users of such a system. There are two distinct parts under investigation, the interaction between traditional libraries involving the seeking ...
Turner, Kristine
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IMPROVING STUDENTS’ READING COMPREHENSION ABILITY THROUGH COOPERATIVE INTEGRATED READING AND COMPOSITION (A Classroom Action Research at Class VIIIA of SMP Negeri 1 Matesih in the Academic Year of 2009/2010) [PDF]
, 2011 Handini, S890908209, “Improving Students’ Reading Comprehension Ability Through Cooperative Integrated Reading and Composition” (A Classroom Action Research at Class VIIIA of SMP Negeri 1 Matesih in the Academic Year of 2009/2010).
HANDINI,
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Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Structural mass spectrometry of membrane proteins within their native lipid environments
Mass spectrometry has emerged as an important structural biology tool for understanding membrane protein structure, function, and dynamics. Generally, structural mass spectrometry of membrane proteins has been performed on purified or reconstituted ...
Reading, Eamonn
core +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Speed reading techniques in the context of reading and comprehension
, 2021 Bilginin çok hızlı üretilip yayılması sebebiyle okunacak materyallerin günden güne artması, buna karşın okumaya ayrılan zamanın giderek azalması, birtakım yenilikleri gerekli kılmaktadır.
Soysal, Taşkın
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