Results 91 to 100 of about 358,190 (262)
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
TRAINING READING SKILLS IN THE FOREIGN LANGUAGE: A COMMUNICATIVE, INTEGRATED SKILLS APPROACH [PDF]
Diversitate si Identitate Culturala in Europa, 2015 The present paper examines a number of effective techniques aimed at building fluent reading skills in the foreign language in a communicative class context.
Angela STĂNESCU
doaj
Reading on small displays: reading performance and perceived ease of reading
The present thesis explores and discusses reading continuous text on small screens, namely on mobile devices, and aims at identifying a model capturing those factors that most influence the perceived experience of reading.
Tikka, Piiastiina
core
Enhancing the Reading Engagement of University English Language Learners: An Action Research Project
, 2015 Despite burgeoning research that has been conducted on the broad term “engagement” in the past decades, research into engagement in English as a Second Language (ESL) or English as a Foreign Language (EFL) contexts remains scarce.
Lee, Jocelyn Yee Vun
core
An investigation of guided reading with beginning readers in the national literacy strategy (1998-2002) [PDF]
, 2004 This thesis reports a research investigation into teachers' practices in, and perceptions of, guided reading in the National Literacy Strategy. The study was framed by two connected debates.
McKay, Mary R., McKay, Mary R
core
READING TECHNIQUES TO IMPROVE PUPILS' READING COMPREHENSION
, 2023 The article dwells on how to construct effective learning techniques to foster reading skills which have been included in the syllabus of each and every primary and secondary ...
Erkinova Anora Akbar qizi +1 more
core
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
BahastraReading interest in Indonesia remains low, negatively affecting students' reading comprehension and productive skills such as writing and speaking. Although various reading techniques have been introduced, their relative effectiveness remains uncertain.
Marlia Marlia, Tran Quoc Si
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source