Results 101 to 110 of about 1,269,047 (315)
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
Microorganisms, 2019 Oxidative stress response protects organisms from deleterious effects of reactive oxygen species (ROS), which can damage cellular components and cause disturbance of the cellular homeostasis.
Huanhuan Shao +8 more
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Reference Reagents -- 1964-67 -- United States Public Health Service -- NIH -- letter, 1967-11-20
, 1967 Letter from National Institue of Allergy and Infectious Diseases National Institutes of Health to Requestors of Information Concerning the distribution of Research Reagents dated 1967-11-20.Sabin Collection Fair Use ...
National Institue of Allergy and Infectious Diseases National Institutes of Health
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Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Studies towards the stereoselective electrophilic amination of carbanions
, 2002 Filip SV. Studies towards the stereoselective electrophilic amination of carbanions. Bielefeld (Germany): Bielefeld University; 2002.A rapid development of novel and more efficient amination methods has been recorded during the past decade, mostly ...
Filip, Sorin V.
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Reactivity of Electrophilic Trifluoromethylating Reagents [PDF]
Kinetics of the reactions of colored carbanions (reference nucleophiles) with S-(trifluoromethyl)dibenzothiophenium ions (Umemoto's reagents) and hypervalent trifluoromethyl-substituted iodine compounds (Togni's reagents) have been determined ...
Timofeeva, Daria S. +3 more
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Status and prospects of oxidized/low rank coal flotation research
Meitan xuebaoThe research progress of oxidized/low rank coal flotation technology is of great significance to improve the utilization efficiency of coal resources. An overview of the research progress on the flotation technology of oxidized/low rank coal is presented,
Hengfei CHEN +6 more
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source