Results 81 to 90 of about 1,325,140 (312)

Handling Pyrophoric Reagents [PDF]

, 2009
Pyrophoric reagents are extremely hazardous. Special handling techniques are required to prevent contact with air and the resulting fire.
Alnajjar, Mikhail S., Haynie, Todd O.
core   +1 more source

Genome-wide identification of the fatty acid desaturases gene family in four Aspergillus species and their expression profile in Aspergillus oryzae

AMB Express, 2018
Fatty acid desaturases play a key role in producing polyunsaturated fatty acids by converting single bonds to double bonds. In the present study, a total of 13, 12, 8 and 8 candidate fatty acid desaturases genes were identified in the Aspergillus oryzae,
Wen Tang, Changsheng Ouyang, Lanlan Liu, Haoran Li, Chuanhui Zeng, Jie Wang, Lijun Fu, Qinqin Wu, Bin Zeng, Bin He   +9 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Studies towards the stereoselective electrophilic amination of carbanions [PDF]

, 2002
Filip SV. Studies towards the stereoselective electrophilic amination of carbanions. Bielefeld (Germany): Bielefeld University; 2002.A rapid development of novel and more efficient amination methods has been recorded during the past decade, mostly ...
Filip, Sorin V.
core  

Organoselenium Compounds Derived from Natural Metabolites

Pharmaceuticals
Background/Objectives: Natural metabolites, due to their abundance, structural diversity, and availability in enantiomerically pure form, are broadly utilized in the synthesis of reagents, catalysts, building blocks, and potential therapeutics.
Agata J. Pacuła-Miszewska, Magdalena Obieziurska-Fabisiak, Jacek Ścianowski   +2 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Transcriptome analysis of different growth stages of Aspergillus oryzae reveals dynamic changes of distinct classes of genes during growth

BMC Microbiology, 2018
Background The gene expression profile and metabolic pathways of Aspergillus oryzae underlying the anatomical and morphological differentiation across different growth stages have not been fully characterized.
Bin He, Zhihong Hu, Long Ma, Haoran Li, Mingqiang Ai, Jizhong Han, Bin Zeng   +6 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Transfer Reagents

, 2021
Fluorinated groups are essential for drug design, agrochemicals, and materials science. The bis(trifluoromethyl)amino group is an example of a stable group that has a high potential.
Hailmann, Michael, Rüdiger Bertermann, Kerpen, Christoph, Zapf, Ludwig, Tanja Knuplez, Deutsch, Carl, Landmann, Johannes, Bischof, Tobias, Nikolai V. Ignat'ev, Maik Finze, Finze, Maik, Klaus Urbahns, Urbahns, Klaus, Ignat'ev, Nikolai V., Kristina A. M. Maibom, Eva‐Maria Tanzer Krauel, Keppner, Fabian, Christoph Kerpen, Michael Hailmann, Johannes Landmann, Knuplez, Tanja, Leon N. Schneider, Tanzer Krauel, Eva-Maria, Maibom, Kristina A. M., Bertermann, Rüdiger, Fabian Keppner, Carl Deutsch, Ludwig Zapf, Tobias Bischof, Schneider, Leon N.   +29 more
core   +1 more source

TSE Diagnostics: Recent Advances in Immunoassaying Prions

Clinical and Developmental Immunology, 2013
Transmissible spongiform encephalopathies (TSEs) or prion diseases are a group of rare fatal neurodegenerative diseases, affecting humans and animals.
Anja Lukan, Tanja Vranac, Vladka Čurin Šerbec   +2 more
doaj   +1 more source