Results 81 to 90 of about 1,269,047 (315)

Genome-wide identification of the fatty acid desaturases gene family in four Aspergillus species and their expression profile in Aspergillus oryzae

AMB Express, 2018
Fatty acid desaturases play a key role in producing polyunsaturated fatty acids by converting single bonds to double bonds. In the present study, a total of 13, 12, 8 and 8 candidate fatty acid desaturases genes were identified in the Aspergillus oryzae,
Wen Tang, Changsheng Ouyang, Lanlan Liu, Haoran Li, Chuanhui Zeng, Jie Wang, Lijun Fu, Qinqin Wu, Bin Zeng, Bin He   +9 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Handling Pyrophoric Reagents [PDF]

, 2009
Pyrophoric reagents are extremely hazardous. Special handling techniques are required to prevent contact with air and the resulting fire.
Alnajjar, Mikhail S., Haynie, Todd O.
core   +1 more source

Organoselenium Compounds Derived from Natural Metabolites

Pharmaceuticals
Background/Objectives: Natural metabolites, due to their abundance, structural diversity, and availability in enantiomerically pure form, are broadly utilized in the synthesis of reagents, catalysts, building blocks, and potential therapeutics.
Agata J. Pacuła-Miszewska, Magdalena Obieziurska-Fabisiak, Jacek Ścianowski   +2 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Transcriptome analysis of different growth stages of Aspergillus oryzae reveals dynamic changes of distinct classes of genes during growth

BMC Microbiology, 2018
Background The gene expression profile and metabolic pathways of Aspergillus oryzae underlying the anatomical and morphological differentiation across different growth stages have not been fully characterized.
Bin He, Zhihong Hu, Long Ma, Haoran Li, Mingqiang Ai, Jizhong Han, Bin Zeng   +6 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

TSE Diagnostics: Recent Advances in Immunoassaying Prions

Clinical and Developmental Immunology, 2013
Transmissible spongiform encephalopathies (TSEs) or prion diseases are a group of rare fatal neurodegenerative diseases, affecting humans and animals.
Anja Lukan, Tanja Vranac, Vladka Čurin Šerbec   +2 more
doaj   +1 more source

Effects on Gene Transcription Profile and Fatty Acid Composition by Genetic Modification of Mevalonate Diphosphate Decarboxylase MVD/Erg19 in Aspergillus Oryzae

Microorganisms, 2019
Mevalonate diphosphate decarboxylase MVD/Erg19 is required for ergosterol biosynthesis, growth, sporulation, and stress tolerance in Aspergillus oryzae.
Zhihong Hu, Hui Huang, Yunlong Sun, Yali Niu, Wangzishuai Xu, Qicong Liu, Zhe Zhang, Chunmiao Jiang, Yongkai Li, Bin Zeng   +9 more
doaj   +1 more source

Negishi's Reagent Versus Rosenthal's Reagent in the Formation of Zirconacyclopentadienes

Chemistry – A European Journal, 2019
AbstractZirconacyclopentadienes are versatile precursors for a large number of heteroles, which are accessible by Zr‐element exchange reactions. The vast majority of reports describe their preparation by the use of Negishi′s reagent, which is a species that is formed in situ.
Sara Urrego‐Riveros, Isabel‐Maria Ramirez y Medina, Daniel Duvinage, Enno Lork, Frank D. Sönnichsen, Anne Staubitz   +5 more
openaire   +2 more sources