Results 111 to 120 of about 3,045,873 (317)

The Little Data Book 2002

open access: yes, 2002
This is the pocket edition of the World Development Indicators for 2002, intended as a quick reference for users. It presents the latest available data for World Bank member countries, and other economies with
World Bank
core   +1 more source

Real-world evidence evaluation of LDL-C in hospitalized patients: a population-based observational study in the timeframe 2021–2022

open access: yesLipids in Health and Disease
Aims European registries and retrospective cohort studies have highlighted the failure to achieve low-density lipoprotein-cholesterol (LDL-C) targets in many very high-risk patients.
Umberto Capece   +7 more
doaj   +1 more source

Cost-effectiveness of the adjuvanted respiratory syncytial virus prefusion F protein (RSVPreF3) vaccine in Japanese adults aged 50–59 years at increased risk of severe RSV disease and those aged ≥60 years

open access: yesExpert Review of Vaccines
Background Respiratory syncytial virus (RSV) can cause substantial morbidity and mortality in adults aged 50–59 years at increased risk of severe RSV disease due to specific underlying conditions (i.e.
Kentaro Tajima   +7 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

The Little Data Book on Private Sector Development 2011

open access: yes, 2011
The little data book on private sector development 2011 is based on world development indicators 2011 and it's accompanying CD-ROM, with a focus on the private sector in development.
World Bank
core   +1 more source

Methods for identifying health status from routinely collected health data: An overview

open access: yesIntegrative Medicine Research
The use of routinely collected health data (RCD) is currently helping to accelerate publications that evaluate the effectiveness and safety of medicines and medical devices.
Mei Liu   +8 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Real-world VRP benchmark data with realistic non-standard constraints - input data and results

open access: yes, 2018
This dataset contains 9 Excel (xls) files that can be used as a new benchmark data for the solving of real-world vehicle routing problems with realistic non-standard constraints.
Žunić, E. (Emir)
core   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

open access: yesMolecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce   +11 more
wiley   +1 more source

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