Results 171 to 180 of about 1,104,681 (217)
Some of the next articles are maybe not open access.
For insights into the real world, consider real-world data
Science Translational Medicine, 2022Randomized control trials (RCTs) are required before drug and device approvals and have contributed to patient safety, but they have also increased the cost and time of regulatory assessments. We propose that using real-world evidence to complement or, in some settings, to replace RCTs will accelerate delivery of new drugs to patients.
Sana Raoof, Razelle Kurzrock
openaire +2 more sources
Real world data (RWD) in pediatrics
Journal of Biopharmaceutical Statistics, 2022Unique challenges pertain when studying children, although many research principles are the same as those when studying adult populations. This truism extends to the use of real-world data (RWD). RWD are particularly relevant to pediatrics because they may potentially provide an additional source of data to inform pediatric labeling and practice ...
Tamar, Lasky, Aloka, Chakravarty
openaire +2 more sources
Oseltamivir: the real world data
BMJ, 2014To coincide with the publication of an updated systematic review by the Cochrane group the BMJ invited Nick Freemantle and colleagues to consider the current status of observational studies of oseltamivir and their influence on policy and ...
Nick, Freemantle +4 more
openaire +2 more sources
Assessing real-world medication data completeness
Journal of Biomedical Informatics, 2021Analysis of healthcare Real-World Data (RWD) provides an opportunity to observe actual patient diagnostic, treatment and outcomes events. However, researchers should understand the possible limitations of RWD. In particular, these data may be incomplete, which would affect the validity of study conclusions.The completeness of medication RWD was ...
Laura, Evans +2 more
openaire +2 more sources
[Real-world evidence vs EBM: what does real-world data add?]
Recenti progressi in medicina, 2021Although randomized clinical trials (RCTs) offer the highest level of scientific evidence, they are unable to evaluate the impact of treatments in the routine clinical practice. The heterogeneity of socio-demographic and clinical characteristics of patients, as well as the complexity of treatments, explain the gap between the effect observed in RCTs ...
Franchi M., Corrao G.
openaire +2 more sources
Drug repurposing using real-world data
Drug Discovery Today, 2023The use of real-world data in drug repurposing has emerged due to well-established advantages of drug repurposing in supplementing de novo drug discovery and incentives in incorporating real-world evidence in regulatory approvals. We conducted a scoping review to characterize repurposing studies using real-world data and discuss their potential ...
George S Q, Tan +4 more
openaire +2 more sources
Real-world data and real-world evidence
Abstract Real-world data (RWD) can be described as routinely collected data from a variety of sources other than traditional clinical trials. A summary of the status of the use of real-world evidence (RWE) in regulatory decision-making is provided.Phil Ambery +2 more
openaire +1 more source
Therapeutic Innovation & Regulatory Science, 2019
The use of real-world data and real-world evidence to inform health care decisions is increasing. Yet, the variable quality of these data and the lack of widely-accepted criteria by which to assess quality create uncertainty about how and when to use these data and the associated evidence in decision making.
Richard E. Gliklich, Michelle B. Leavy
openaire +2 more sources
The use of real-world data and real-world evidence to inform health care decisions is increasing. Yet, the variable quality of these data and the lack of widely-accepted criteria by which to assess quality create uncertainty about how and when to use these data and the associated evidence in decision making.
Richard E. Gliklich, Michelle B. Leavy
openaire +2 more sources
The Evolving Uses of “Real-World” Data
JAMA, 2019The terms real-world data (RWD) and real-world evidence (RWE) have entered the medical lexicon to refer to data sources and analyses characterizing routine health care delivery. RWD and RWE are most often defined by what they are not: information from experiments such as randomized clinical trials.
Ethan, Basch, Deborah, Schrag
openaire +2 more sources